UCSF

Nuclear Factor NF-kappa-B P105 Subunit, Human (46 Compounds)

Swissprot:
NFKB1_HUMAN
Stitch:
NFKB1_HUMAN
UniProt:
P19838
ChEMBL:
CHEMBL3251
Reactome:
REACT_118656
REACT_163773
REACT_12555
REACT_163994
REACT_23950
REACT_22442
REACT_13696
REACT_13443
REACT_118563
REACT_169168
REACT_21281
REACT_24969
REACT_27161
PDB:
1MDI (DOCK)
1MDJ (DOCK)
1MDK (DOCK)
1NFI (DOCK)
1SVC (DOCK)
2DBF (DOCK)
2O61 (DOCK)
3GUT (DOCK)
NFKB1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 46 5 4 0
Binding ≤ 1μM 18 1 0 0
Functional ≤ 10μM 68 0 0 0

Reactome Network (13)

Reactome ID Description Species
REACT_118656 Activation of NF-kappaB in B cells Homo sapiens
REACT_163773 DEx/H-box helicases activate type I IFN and inflammatory cytokines production Homo sapiens
REACT_12555 Downstream TCR signaling Homo sapiens
REACT_163994 FCERI mediated NF-kB activation Homo sapiens
REACT_23950 Interleukin-1 processing Homo sapiens
REACT_22442 Interleukin-1 signaling Homo sapiens
REACT_13696 NF-kB is activated and signals survival Homo sapiens
REACT_13443 Regulated proteolysis of p75NTR Homo sapiens
REACT_118563 RIP-mediated NFkB activation via ZBP1 Homo sapiens
REACT_169168 Senescence-Associated Secretory Phenotype (SASP) Homo sapiens
REACT_21281 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Homo sapiens
REACT_24969 TRAF6 mediated NF-kB activation Homo sapiens
REACT_27161 Transcriptional regulation of white adipocyte differentiation Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKBE_HUMAN O00221 CHEMBL3407 NF-kappaB Inhibitor Epsilon, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

DEx/H-box helicases activate type I IFN and inflammatory cytokines production

Uniprot Swissprot Chembl Description Number Shared
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

Downstream TCR signaling

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

FCERI mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

Interleukin-1 processing

Uniprot Swissprot Chembl Description Number Shared
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

Interleukin-1 signaling

Uniprot Swissprot Chembl Description Number Shared
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1

NF-kB is activated and signals survival

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

Regulated proteolysis of p75NTR

Uniprot Swissprot Chembl Description Number Shared
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

RIP-mediated NFkB activation via ZBP1

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

Senescence-Associated Secretory Phenotype (SASP)

Uniprot Swissprot Chembl Description Number Shared
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 66
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 79
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

TRAF6 mediated NF-kB activation

Uniprot Swissprot Chembl Description Number Shared
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKKA_HUMAN O15111 CHEMBL3476 Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit, Human 1
IKKB_HUMAN O14920 CHEMBL1991 Inhibitor Of Nuclear Factor Kappa B Kinase Beta Subunit, Human 1
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 90
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28

Transcriptional regulation of white adipocyte differentiation

Uniprot Swissprot Chembl Description Number Shared
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 22 0 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
NFKB1-1-E Nuclear Factor NF-kappa-B P105 Subunit (cluster #1 Of 2), Eukaryotic 45 5 4 0
NFKB1-2-E Nuclear Factor NF-kappa-B P105 Subunit (cluster #2 Of 2), Eukaryotic 1 0 0 0
Uniprot Swissprot Chembl Description Number Shared
NFKB2_HUMAN Q00653 CHEMBL3003 Nuclear Factor NF-kappa-B P100/p49 Subunits, Human 90
JUN_HUMAN P05412 CHEMBL4977 Proto-oncogene C-JUN, Human 79
FOS_HUMAN P01100 CHEMBL5029 Proto-oncogene Protein C-fos, Human 66
Z81072 Z81072 CHEMBL397 Jurkat (Acute Leukemic T-cells) 66
TF65_HUMAN Q04206 CHEMBL5533 Nuclear Factor NF-kappa-B P65 Subunit, Human 28
ATF1_HUMAN P18846 CHEMBL3255 Activating Transcription Factor 1, Human 18
IKBA_HUMAN P25963 CHEMBL2898 NF-kappaB Inhibitor Alpha, Human 8
IKBB_HUMAN Q15653 CHEMBL3806 NF-kappaB Inhibitor Beta, Human 8
IKBE_HUMAN O00221 CHEMBL3407 NF-kappaB Inhibitor Epsilon, Human 8