UCSF

Phosphodiesterase 1B, Human (181 Compounds)

Swissprot:
PDE1B_HUMAN
Stitch:
PDE1B_HUMAN
UniProt:
Q01064
ChEMBL:
CHEMBL4425
Reactome:
REACT_15408
REACT_23767
REACT_19327
PDB:
1LXR (DOCK)
1TAZ (DOCK)
PDE1B

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 181 21 8 8
Binding ≤ 1μM 67 7 2 2
Functional ≤ 10μM 7 1 1 1

Reactome Network (3)

Reactome ID Description Species
REACT_15408 Cam-PDE 1 activation Homo sapiens
REACT_23767 cGMP effects Homo sapiens
REACT_19327 G alpha (s) signalling events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 185
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 185

cGMP effects

Uniprot Swissprot Chembl Description Number Shared
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 5
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 2
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 185
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 5
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 46
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 37
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 104
PDE9A_HUMAN O76083 CHEMBL3535 Phosphodiesterase 9A, Human 2

G alpha (s) signalling events

Uniprot Swissprot Chembl Description Number Shared
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 5
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 2
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 185
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 5
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 46
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 37
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 30
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 30
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 30
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 54
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 28
PDE7B_HUMAN Q9NP56 CHEMBL4716 Phosphodiesterase 7B, Human 5
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 77 7 4 4
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 35 7 3 3

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PDE1A_HUMAN P54750 CHEMBL3421 Phosphodiesterase 1A, Human 185
PDE1C_HUMAN Q14123 CHEMBL4619 Phosphodiesterase 1C, Human 185
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 104
PDE4D_HUMAN Q08499 CHEMBL288 Phosphodiesterase 4D, Human 54
PDE3A_HUMAN Q14432 CHEMBL241 Phosphodiesterase 3A, Human 46
PDE3B_HUMAN Q13370 CHEMBL290 Phosphodiesterase 3B, Human 37
PDE4A_HUMAN P27815 CHEMBL254 Phosphodiesterase 4A, Human 30
PDE4B_HUMAN Q07343 CHEMBL275 Phosphodiesterase 4B, Human 30
PDE4C_HUMAN Q08493 CHEMBL291 Phosphodiesterase 4C, Human 30
PDE7A_HUMAN Q13946 CHEMBL3012 Phosphodiesterase 7A, Human 28
O77823_PIG O77823 CHEMBL3333 Phosphodiesterase 4A, Pig 27
PDE1A_BOVIN P14100 CHEMBL3774 Phosphodiesterase 1A, Bovin 8
Q864F1_PIG Q864F1 CHEMBL3634 Phosphodiesterase 5, Pig 8
PDE1B_RAT Q01066 CHEMBL3665 Phosphodiesterase 1B, Rat 7
PDE1B_BOVIN Q01061 CHEMBL2650 Phosphodiesterase 1B, Bovin 6
PDE10_HUMAN Q9Y233 CHEMBL4409 Phosphodiesterase 10A, Human 5
PDE2A_HUMAN O00408 CHEMBL2652 Phosphodiesterase 2A, Human 5
PDE7B_HUMAN Q9NP56 CHEMBL4716 Phosphodiesterase 7B, Human 5
PDE1C_RAT Q63421 CHEMBL2651 Phosphodiesterase 1C, Rat 4
Q9EPR9_RAT Q9EPR9 CHEMBL2740 Phosphodiesterase 1A, Rat 4
CNCG_HUMAN Q13956 CHEMBL2341 Phosphodiesterase 6H, Human 3
CNRG_HUMAN P18545 CHEMBL2415 Phosphodiesterase 6G, Human 3
E1BN64_BOVIN E1BN64 CHEMBL5129 Phosphodiesterase 3B, Bovin 3
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 3
PDE5A_BOVIN Q28156 CHEMBL3478 Phosphodiesterase 5A, Bovin 3
PDE6A_HUMAN P16499 CHEMBL3878 Phosphodiesterase 6A, Human 3
PDE6B_HUMAN P35913 CHEMBL3659 Phosphodiesterase 6B, Human 3
PDE6C_HUMAN P51160 CHEMBL3977 Phosphodiesterase 6C, Human 3
PDE6D_HUMAN O43924 CHEMBL3860 Phosphodiesterase 6D, Human 3
CNCG_BOVIN P22571 CHEMBL4606 Phosphodiesterase 6H, Bovin 2
CNRG_BOVIN P04972 CHEMBL5111 Phosphodiesterase 6G, Bovin 2
ESR1_HUMAN P03372 CHEMBL206 Estrogen Receptor Alpha, Human 2
ESR2_HUMAN Q92731 CHEMBL242 Estrogen Receptor Beta, Human 2
PDE11_HUMAN Q9HCR9 CHEMBL2717 Phosphodiesterase 11A, Human 2
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 2
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 2
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 2
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 2
PDE6A_BOVIN P11541 CHEMBL3741 Phosphodiesterase 6A, Bovin 2
PDE6B_BOVIN P23439 CHEMBL2713 Phosphodiesterase 6B, Bovin 2
PDE6C_BOVIN P16586 CHEMBL3479 Phosphodiesterase 6C, Bovin 2
PDE6D_BOVIN Q95142 CHEMBL5110 Phosphodiesterase 6D, Bovin 2
PDE7A_RAT O08593 CHEMBL3450 Phosphodiesterase 7A, Rat 2
PDE9A_HUMAN O76083 CHEMBL3535 Phosphodiesterase 9A, Human 2
Q9XSW7_PIG Q9XSW7 CHEMBL3061 Phosphodiesterase 3A, Pig 2
AA1R_BOVIN P28190 CHEMBL4975 Adenosine A1 Receptor, Bovin 1
AA1R_HUMAN P30542 CHEMBL226 Adenosine A1 Receptor, Human 1
AA1R_RAT P25099 CHEMBL318 Adenosine A1 Receptor, Rat 1
AA2AR_CAVPO P46616 CHEMBL2605 Adenosine A2a Receptor, Guinea Pig 1
AA2AR_RAT P30543 CHEMBL302 Adenosine A2a Receptor, Rat 1
AA2BR_RAT P29276 CHEMBL2592 Adenosine A2b Receptor, Rat 1
AA3R_RAT P28647 CHEMBL3360 Adenosine A3 Receptor, Rat 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
ERG2_YEAST P32352 CHEMBL3224 C-8 Sterol Isomerase, Yeast 1
MDR1_HUMAN P08183 CHEMBL4302 P-glycoprotein 1, Human 1
PDE10_RAT Q9QYJ6 CHEMBL6140 CAMP And CAMP-inhibited CGMP 3',5'-cyclic Phosphodiesterase 10A, Rat 1
PDE2A_BOVIN P14099 CHEMBL3477 Phosphodiesterase 2A, Bovin 1
PDE5A_RAT O54735 CHEMBL4567 Phosphodiesterase 5A, Rat 1
Q8AWE3_CHICK Q8AWE3 CHEMBL2669 Serine-threonine Protein Phosphatase 2A Regulatory Subunit, Chick 1
Q8VIE4_RAT Q8VIE4 CHEMBL3386 Phosphodiesterase 7B, Rat 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 1
Z100267 Z100267 CHEMBL612409 Anti-estrogen Binding Site (AEBS) 1
Z50590 Z50590 CHEMBL613488 Sus Scrofa 1
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 1
Z80224 Z80224 CHEMBL387 MCF7 (Breast Carcinoma Cells) 1
Z81068 Z81068 CHEMBL614649 Ishikawa (Uterine Carcinoma Cells) 1

Most Common Rings