UCSF

PI3-kinase P110-alpha Subunit, Mouse (3 Compounds)

Swissprot:
PK3CA_MOUSE
Stitch:
PK3CA_MOUSE
UniProt:
P42337
ChEMBL:
CHEMBL2499
Reactome:
REACT_226151
REACT_196588
REACT_225477
REACT_188185
REACT_230639
REACT_225145
REACT_204733
REACT_207651
REACT_206286
REACT_220092
REACT_210793
REACT_225836
REACT_257032
REACT_223993
REACT_240139
REACT_215348
REACT_203296
REACT_205300
REACT_226341
REACT_198634
REACT_213364
REACT_210240
REACT_199123
REACT_196455
REACT_196460
REACT_188578
REACT_198973
REACT_211860
REACT_257088
PDB:
4A55 (DOCK)
Pik3ca

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 3 3 2 1
Binding ≤ 1μM 2 2 1 1

Reactome Network (29)

Reactome ID Description Species
REACT_226151 CD28 dependent PI3K/Akt signaling Mus musculus
REACT_196588 Constitutive PI3K/AKT Signaling in Cancer Mus musculus
REACT_225477 Costimulation by the CD28 family Mus musculus
REACT_188185 DAP12 signaling Mus musculus
REACT_230639 Downstream signal transduction Mus musculus
REACT_225145 Downstream TCR signaling Mus musculus
REACT_204733 G alpha (12/13) signalling events Mus musculus
REACT_207651 G alpha (q) signalling events Mus musculus
REACT_206286 GAB1 signalosome Mus musculus
REACT_220092 GPVI-mediated activation cascade Mus musculus
REACT_210793 Interleukin receptor SHC signaling Mus musculus
REACT_225836 Interleukin-3, 5 and GM-CSF signaling Mus musculus
REACT_257032 Nephrin interactions Mus musculus
REACT_223993 PI-3K cascade Mus musculus
REACT_240139 PI3K Cascade Mus musculus
REACT_215348 PI3K events in ERBB2 signaling Mus musculus
REACT_203296 PI3K events in ERBB4 signaling Mus musculus
REACT_205300 PI3K/AKT activation Mus musculus
REACT_226341 PIP3 activates AKT signaling Mus musculus
REACT_198634 Regulation of signaling by CBL Mus musculus
REACT_213364 Role of LAT2/NTAL/LAB on calcium mobilization Mus musculus
REACT_210240 Role of phospholipids in phagocytosis Mus musculus
REACT_199123 Signaling by constitutively active EGFR Mus musculus
REACT_196455 Signaling by FGFR mutants Mus musculus
REACT_196460 Signaling by FGFR1 fusion mutants Mus musculus
REACT_188578 Signaling by SCF-KIT Mus musculus
REACT_198973 Synthesis of PIPs at the plasma membrane Mus musculus
REACT_211860 Tie2 Signaling Mus musculus
REACT_257088 VEGFA-VEGFR2 Pathway Mus musculus
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PK3CA_BOVIN P32871 CHEMBL2498 PI3-kinase P110-alpha Subunit, Bovin 33 6 1 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1,234 42 4 9

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
PK3CA-1-E PI3-kinase P110-alpha Subunit (cluster #1 Of 2), Eukaryotic 12 0 0 0
PK3CA-2-E PI3-kinase P110-alpha Subunit (cluster #2 Of 2), Eukaryotic 1,257 47 5 9
Uniprot Swissprot Chembl Description Number Shared
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 3
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 2
GSK3B_HUMAN P49841 CHEMBL262 Glycogen Synthase Kinase-3 Beta, Human 1
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 1
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 1
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 1
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 1
PIM3_HUMAN Q86V86 CHEMBL5407 Serine/threonine-protein Kinase PIM3, Human 1
PK3CA_BOVIN P32871 CHEMBL2498 PI3-kinase P110-alpha Subunit, Bovin 1
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 1
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 1
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 1
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 1