UCSF

Tyrosine- And Threonine-specific Cdc2-inhibitory Kinase, Human (3 Compounds)

Swissprot:
PMYT1_HUMAN
Stitch:
PMYT1_HUMAN
UniProt:
Q99640
ChEMBL:
CHEMBL3984
Reactome:
REACT_1857
REACT_1574
REACT_1846
REACT_1006
PDB:
3P1A (DOCK)
PKMYT1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 3 3 2 2
Binding ≤ 1μM 2 2 2 2

Reactome Network (4)

Reactome ID Description Species
REACT_1857 Cyclin A/B1 associated events during G2/M transition Homo sapiens
REACT_1574 Cyclin E associated events during G1/S transition Homo sapiens
REACT_1846 G2/M DNA replication checkpoint Homo sapiens
REACT_1006 Polo-like kinase mediated events Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 2

Cyclin E associated events during G1/S transition

Uniprot Swissprot Chembl Description Number Shared
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 2

G2/M DNA replication checkpoint

Uniprot Swissprot Chembl Description Number Shared
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 2

Polo-like kinase mediated events

Uniprot Swissprot Chembl Description Number Shared
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 2

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
ABL1_HUMAN P00519 CHEMBL1862 Tyrosine-protein Kinase ABL, Human 2
ABL2_HUMAN P42684 CHEMBL4014 Tyrosine-protein Kinase ABL2, Human 2
ACK1_HUMAN Q07912 CHEMBL4599 Tyrosine Kinase Non-receptor Protein 2, Human 2
BLK_HUMAN P51451 CHEMBL2250 Tyrosine-protein Kinase BLK, Human 2
BMX_HUMAN P51813 CHEMBL3834 Tyrosine-protein Kinase BMX, Human 2
BTK_HUMAN Q06187 CHEMBL5251 Tyrosine-protein Kinase BTK, Human 2
CHK1_HUMAN O14757 CHEMBL4630 Serine/threonine-protein Kinase Chk1, Human 2
CSF1R_HUMAN P07333 CHEMBL1844 Macrophage Colony Stimulating Factor Receptor, Human 2
CSK_HUMAN P41240 CHEMBL2634 Tyrosine-protein Kinase CSK, Human 2
DMPK_HUMAN Q09013 CHEMBL5320 Myotonin-protein Kinase, Human 2
E2AK4_HUMAN Q9P2K8 CHEMBL5358 Eukaryotic Translation Initiation Factor 2-alpha Kinase 4, Human 2
EGFR_HUMAN P00533 CHEMBL203 Epidermal Growth Factor Receptor ErbB1, Human 2
EPHA3_HUMAN P29320 CHEMBL4954 Ephrin Type-A Receptor 3, Human 2
EPHA5_HUMAN P54756 CHEMBL3987 Ephrin Type-A Receptor 5, Human 2
EPHA8_HUMAN P29322 CHEMBL4134 Ephrin Type-A Receptor 8, Human 2
EPHB1_HUMAN P54762 CHEMBL5072 Ephrin Type-B Receptor 1, Human 2
EPHB4_HUMAN P54760 CHEMBL5147 Ephrin Type-B Receptor 4, Human 2
ERBB2_HUMAN P04626 CHEMBL1824 Receptor Protein-tyrosine Kinase ErbB-2, Human 2
FGR_HUMAN P09769 CHEMBL4454 Tyrosine-protein Kinase FGR, Human 2
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 2
FRK_HUMAN P42685 CHEMBL4223 Tyrosine-protein Kinase FRK, Human 2
FYN_HUMAN P06241 CHEMBL1841 Tyrosine-protein Kinase FYN, Human 2
GAK_HUMAN O14976 CHEMBL4355 Serine/threonine-protein Kinase GAK, Human 2
HCK_HUMAN P08631 CHEMBL3234 Tyrosine-protein Kinase HCK, Human 2
JAK2_HUMAN O60674 CHEMBL2971 Tyrosine-protein Kinase JAK2, Human 2
KC1E_HUMAN P49674 CHEMBL4937 Casein Kinase I Epsilon, Human 2
KSYK_HUMAN P43405 CHEMBL2599 Tyrosine-protein Kinase SYK, Human 2
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 2
LYN_HUMAN P07948 CHEMBL3905 Tyrosine-protein Kinase Lyn, Human 2
M3K4_HUMAN Q9Y6R4 CHEMBL4853 Mitogen-activated Protein Kinase Kinase Kinase 4, Human 2
M4K1_HUMAN Q92918 CHEMBL5749 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 2
M4K3_HUMAN Q8IVH8 CHEMBL5432 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 2
M4K4_HUMAN O95819 CHEMBL6166 Mitogen-activated Protein Kinase Kinase Kinase Kinase 4, Human 2
M4K5_HUMAN Q9Y4K4 CHEMBL4852 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 2
MLTK_HUMAN Q9NYL2 CHEMBL3886 Mixed Lineage Kinase 7, Human 2
MP2K1_HUMAN Q02750 CHEMBL3587 Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human 2
MP2K2_HUMAN P36507 CHEMBL2964 Dual Specificity Mitogen-activated Protein Kinase Kinase 2, Human 2
SIK2_HUMAN Q9H0K1 CHEMBL5699 Serine/threonine-protein Kinase SIK2, Human 2
SLK_HUMAN Q9H2G2 CHEMBL4202 Serine/threonine-protein Kinase 2, Human 2
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 2
STK10_HUMAN O94804 CHEMBL3981 Serine/threonine-protein Kinase 10, Human 2
STK36_HUMAN Q9NRP7 CHEMBL4312 Serine/threonine-protein Kinase 36, Human 2
TBA1A_RAT P68370 CHEMBL4139 Tubulin Alpha-1 Chain, Rat 2
TNI3K_HUMAN Q59H18 CHEMBL5260 Serine/threonine-protein Kinase TNNI3K, Human 2
TNIK_HUMAN Q9UKE5 CHEMBL4527 TRAF2- And NCK-interacting Kinase, Human 2
TXK_HUMAN P42681 CHEMBL4367 Tyrosine-protein Kinase TXK, Human 2
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 2
WEE1_HUMAN P30291 CHEMBL5491 Serine/threonine-protein Kinase WEE1, Human 2
YES_HUMAN P07947 CHEMBL2073 Tyrosine-protein Kinase YES, Human 2
AAK1_HUMAN Q2M2I8 CHEMBL3830 Adaptor-associated Kinase, Human 1
ACV1B_HUMAN P36896 CHEMBL5310 Activin Receptor Type-1B, Human 1
ACVL1_HUMAN P37023 CHEMBL5311 Serine/threonine-protein Kinase Receptor R3, Human 1
ACVR1_HUMAN Q04771 CHEMBL5903 Activin Receptor Type-1, Human 1
ADCK3_HUMAN Q8NI60 CHEMBL5550 Chaperone Activity Of Bc1 Complex-like, Mitochondrial, Human 1
ADCK4_HUMAN Q96D53 CHEMBL5753 Uncharacterized AarF Domain-containing Protein Kinase 4, Human 1
ALK_HUMAN Q9UM73 CHEMBL4247 ALK Tyrosine Kinase Receptor, Human 1
AURKB_HUMAN Q96GD4 CHEMBL2185 Serine/threonine-protein Kinase Aurora-B, Human 1
AVR2A_HUMAN P27037 CHEMBL5616 Activin Receptor Type-2A, Human 1
AVR2B_HUMAN Q13705 CHEMBL5466 Activin Receptor Type-2B, Human 1
BCR_HUMAN P11274 CHEMBL5146 Breakpoint Cluster Region Protein, Human 1
BLK_MOUSE P16277 CHEMBL3343 Tyrosine-protein Kinase BLK, Mouse 1
BMP2K_HUMAN Q9NSY1 CHEMBL4522 BMP-2-inducible Protein Kinase, Human 1
BRAF_HUMAN P15056 CHEMBL5145 Serine/threonine-protein Kinase B-raf, Human 1
CDK16_HUMAN Q00536 CHEMBL4597 Serine/threonine-protein Kinase PCTAIRE-1, Human 1
CLK1_HUMAN P49759 CHEMBL4224 Dual Specificty Protein Kinase CLK1, Human 1
CLK2_HUMAN P49760 CHEMBL4225 Dual Specificity Protein Kinase CLK2, Human 1
CLK3_HUMAN P49761 CHEMBL4226 Dual Specificity Protein Kinase CLK3, Human 1
CLK4_HUMAN Q9HAZ1 CHEMBL4203 Dual Specificity Protein Kinase CLK4, Human 1
CTRO_HUMAN O14578 CHEMBL5579 Citron Rho-interacting Kinase, Human 1
DAPK3_HUMAN O43293 CHEMBL2468 Death-associated Protein Kinase 3, Human 1
DCLK3_HUMAN Q9C098 CHEMBL6123 Serine/threonine-protein Kinase DCLK3, Human 1
DDR1_HUMAN Q08345 CHEMBL5319 Epithelial Discoidin Domain-containing Receptor 1, Human 1
DDR2_HUMAN Q16832 CHEMBL5122 Discoidin Domain-containing Receptor 2, Human 1
DYR1B_HUMAN Q9Y463 CHEMBL5543 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 1
E2AK2_HUMAN P19525 CHEMBL5785 Interferon-induced, Double-stranded RNA-activated Protein Kinase, Human 1
EPHA1_HUMAN P21709 CHEMBL5810 Ephrin Type-A Receptor 1, Human 1
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 1
EPHA4_HUMAN P54764 CHEMBL3988 Ephrin Type-A Receptor 4, Human 1
EPHA6_HUMAN Q9UF33 CHEMBL4526 Ephrin Type-A Receptor 6, Human 1
EPHB2_HUMAN P29323 CHEMBL3290 Ephrin Type-B Receptor 2, Human 1
EPHB3_HUMAN P54753 CHEMBL4901 Ephrin Type-B Receptor 3, Human 1
FAK1_HUMAN Q05397 CHEMBL2695 Focal Adhesion Kinase 1, Human 1
FER_HUMAN P16591 CHEMBL3982 Tyrosine-protein Kinase FER, Human 1
FES_HUMAN P07332 CHEMBL5455 Tyrosine-protein Kinase FES, Human 1
FGFR1_HUMAN P11362 CHEMBL3650 Fibroblast Growth Factor Receptor 1, Human 1
FGFR2_HUMAN P21802 CHEMBL4142 Fibroblast Growth Factor Receptor 2, Human 1
ITK_HUMAN Q08881 CHEMBL2959 Tyrosine-protein Kinase ITK/TSK, Human 1
JAK3_HUMAN P52333 CHEMBL2148 Tyrosine-protein Kinase JAK3, Human 1
KC1AL_HUMAN Q8N752 CHEMBL5520 Casein Kinase I Isoform Alpha-like, Human 1
KC1A_HUMAN P48729 CHEMBL2793 Casein Kinase I Alpha, Human 1
KC1D_HUMAN P48730 CHEMBL2828 Casein Kinase I Delta, Human 1
KCC1D_HUMAN Q8IU85 CHEMBL5073 CaM Kinase I Delta, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
KKCC1_HUMAN Q8N5S9 CHEMBL5256 CaM-kinase Kinase Alpha, Human 1
KKCC2_HUMAN Q96RR4 CHEMBL5284 CaM-kinase Kinase Beta, Human 1
KPCD_HUMAN Q05655 CHEMBL2996 Protein Kinase C Delta, Human 1
KS6A2_HUMAN Q15349 CHEMBL3906 Ribosomal Protein S6 Kinase Alpha 2, Human 1
LCK_MOUSE P06240 CHEMBL2480 Tyrosine-protein Kinase LCK, Mouse 1
LIMK1_HUMAN P53667 CHEMBL3836 LIM Domain Kinase 1, Human 1
LIMK2_HUMAN P53671 CHEMBL5932 LIM Domain Kinase 2, Human 1
MARK1_HUMAN Q9P0L2 CHEMBL5940 Serine/threonine-protein Kinase MARK1, Human 1
MERTK_HUMAN Q12866 CHEMBL5331 Proto-oncogene Tyrosine-protein Kinase MER, Human 1
MET_HUMAN P08581 CHEMBL3717 Hepatocyte Growth Factor Receptor, Human 1
MK11_HUMAN Q15759 CHEMBL3961 MAP Kinase P38 Beta, Human 1
MK12_HUMAN P53778 CHEMBL4674 MAP Kinase P38 Gamma, Human 1
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 1
MK14_HUMAN Q16539 CHEMBL260 MAP Kinase P38 Alpha, Human 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
MRCKB_HUMAN Q9Y5S2 CHEMBL5052 Serine/threonine-protein Kinase MRCK Beta, Human 1
MRCKG_HUMAN Q6DT37 CHEMBL5615 Serine/threonine-protein Kinase MRCK Gamma, Human 1
MST4_HUMAN Q9P289 CHEMBL5941 Serine/threonine-protein Kinase MST4, Human 1
MYLK2_HUMAN Q9H1R3 CHEMBL2777 Myosin Light Chain Kinase 2, Human 1
NEK1_HUMAN Q96PY6 CHEMBL5855 Serine/threonine-protein Kinase Nek1, Human 1
NEK2_HUMAN P51955 CHEMBL3835 Serine/threonine-protein Kinase NEK2, Human 1
NLK_HUMAN Q9UBE8 CHEMBL5364 Serine/threonine Protein Kinase NLK, Human 1
NUAK2_HUMAN Q9H093 CHEMBL5698 NUAK Family SNF1-like Kinase 2, Human 1
PAK1_HUMAN Q13153 CHEMBL4600 Serine/threonine-protein Kinase PAK 1, Human 1
PGFRA_HUMAN P16234 CHEMBL2007 Platelet-derived Growth Factor Receptor Alpha, Human 1
PGFRB_HUMAN P09619 CHEMBL1913 Platelet-derived Growth Factor Receptor Beta, Human 1
PHKG1_HUMAN Q16816 CHEMBL4004 Phosphorylase Kinase Gamma Subunit 1, Human 1
PHKG2_HUMAN P15735 CHEMBL2349 Phosphorylase Kinase Gamma Subunit 2, Human 1
PI42B_HUMAN P78356 CHEMBL5667 Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta, Human 1
PTK6_HUMAN Q13882 CHEMBL4601 Tyrosine-protein Kinase BRK, Human 1
RAF1_HUMAN P04049 CHEMBL1906 Serine/threonine-protein Kinase RAF, Human 1
RET_HUMAN P07949 CHEMBL2041 Tyrosine-protein Kinase Receptor RET, Human 1
RIPK2_HUMAN O43353 CHEMBL5014 Serine/threonine-protein Kinase RIPK2, Human 1
SIK1_HUMAN P57059 CHEMBL6082 Serine/threonine-protein Kinase SIK1, Human 1
SRC_CHICK P00523 CHEMBL3655 Tyrosine-protein Kinase SRC, Chick 1
SRMS_HUMAN Q9H3Y6 CHEMBL5703 Tyrosine-protein Kinase Srms, Human 1
ST17A_HUMAN Q9UEE5 CHEMBL4525 Serine/threonine-protein Kinase 17A, Human 1
ST17B_HUMAN O94768 CHEMBL3980 Serine/threonine-protein Kinase 17B, Human 1
ST32B_HUMAN Q9NY57 CHEMBL5912 Serine/threonine-protein Kinase 32B, Human 1
ST38L_HUMAN Q9Y2H1 CHEMBL4851 Serine/threonine-protein Kinase 38-like, Human 1
STK24_HUMAN Q9Y6E0 CHEMBL5082 Serine/threonine-protein Kinase 24, Human 1
STK25_HUMAN O00506 CHEMBL5552 Serine/threonine-protein Kinase 25, Human 1
STK33_HUMAN Q9BYT3 CHEMBL6005 Serine/threonine-protein Kinase 33, Human 1
STK3_HUMAN Q13188 CHEMBL4708 Serine/threonine-protein Kinase MST2, Human 1
STK3_MOUSE Q9JI10 CHEMBL4310 Serine/threonine-protein Kinase MST2, Mouse 1
STK4_HUMAN Q13043 CHEMBL4598 Serine/threonine-protein Kinase MST1, Human 1
TEC_HUMAN P42680 CHEMBL4246 Tyrosine-protein Kinase TEC, Human 1
TESK1_HUMAN Q15569 CHEMBL5604 Dual Specificity Testis-specific Protein Kinase 1, Human 1
TGFR1_HUMAN P36897 CHEMBL4439 TGF-beta Receptor Type I, Human 1
TGFR2_HUMAN P37173 CHEMBL4267 TGF-beta Receptor Type II, Human 1
TIE1_HUMAN P35590 CHEMBL5274 Tyrosine-protein Kinase Receptor Tie-1, Human 1
TIE2_HUMAN Q02763 CHEMBL4128 Tyrosine-protein Kinase TIE-2, Human 1
TYRO3_HUMAN Q06418 CHEMBL5314 Tyrosine-protein Kinase Receptor TYRO3, Human 1
UFO_HUMAN P30530 CHEMBL4895 Tyrosine-protein Kinase Receptor UFO, Human 1
ULK3_MOUSE Q3U3Q1 CHEMBL3832 ULK3 Kinase, Mouse 1
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 1