ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (1,414)
Reactome (11)
Related By:
Pathway (7)
Organism (3)
Gene (0)
Org. Clust. (2)
ChEMBL (31)
Rings (28)

Peroxisome Proliferator-activated Receptor Alpha, Human (1,414 Compounds)

Swissprot:: PPARA_HUMAN
Stitch:: PPARA_HUMAN
UniProt:: Q07869
ChEMBL:: CHEMBL239
Reactome:: REACT_147904; REACT_111118; REACT_24941; REACT_15525; REACT_116145; REACT_19241; REACT_118789; REACT_118659; REACT_200608; REACT_27161; REACT_118713
PDB:: 1I7G (DOCK); 1K7L (DOCK); 1KKQ (DOCK); 2NPA (DOCK); 2P54 (DOCK); 2REW (DOCK); 2ZNN (DOCK); 3ET1 (DOCK); 3FEI (DOCK); 3G8I (DOCK); 3KDT (DOCK); 3KDU (DOCK); 3SP6 (DOCK); PPARA

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	1,414	22	16	24
Binding ≤ 1μM	951	13	9	17
Functional ≤ 10μM	1,484	19	14	21

Reactome ID	Description	Species
REACT_147904	Activation of gene expression by SREBF (SREBP)	Homo sapiens
REACT_111118	BMAL1:CLOCK,NPAS2 activates circadian gene expression	Homo sapiens
REACT_24941	Circadian Clock	Homo sapiens
REACT_15525	Nuclear Receptor transcription pathway	Homo sapiens
REACT_116145	PPARA activates gene expression	Homo sapiens
REACT_19241	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp	Homo sapiens
REACT_118789	REV-ERBA represses gene expression	Homo sapiens
REACT_118659	RORA activates circadian gene expression	Homo sapiens
REACT_200608	Transcriptional activation of mitochondrial biogenesis	Homo sapiens
REACT_27161	Transcriptional regulation of white adipocyte differentiation	Homo sapiens
REACT_118713	YAP1- and WWTR1 (TAZ)-stimulated gene expression	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

BMAL1:CLOCK,NPAS2 activates circadian gene expression

Uniprot	Swissprot	Chembl	Description	Number Shared
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

Circadian Clock

Uniprot	Swissprot	Chembl	Description	Number Shared
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

Nuclear Receptor transcription pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
NR1H2_HUMAN	P55055	CHEMBL4093	LXR-beta, Human	19
PPARD_HUMAN	Q03181	CHEMBL3979	Peroxisome Proliferator-activated Receptor Delta, Human	902
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1863
RARG_HUMAN	P13631	CHEMBL2003	Retinoic Acid Receptor Gamma, Human	2
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

PPARA activates gene expression

Uniprot	Swissprot	Chembl	Description	Number Shared
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1863
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp

Uniprot	Swissprot	Chembl	Description	Number Shared
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

REV-ERBA represses gene expression

Uniprot	Swissprot	Chembl	Description	Number Shared
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

RORA activates circadian gene expression

Uniprot	Swissprot	Chembl	Description	Number Shared
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

Transcriptional activation of mitochondrial biogenesis

Uniprot	Swissprot	Chembl	Description	Number Shared
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

Transcriptional regulation of white adipocyte differentiation

Uniprot	Swissprot	Chembl	Description	Number Shared
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1863
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

YAP1- and WWTR1 (TAZ)-stimulated gene expression

Uniprot	Swissprot	Chembl	Description	Number Shared
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
PPARA_CANFA	Q95N78	CHEMBL2847	Peroxisome Proliferator-activated Receptor Alpha, Canine	35	0	0	0
PPARA_MOUSE	P23204	CHEMBL2128	Peroxisome Proliferator-activated Receptor Alpha, Mouse	32	5	4	6
PPARA_RAT	P37230	CHEMBL2129	Peroxisome Proliferator-activated Receptor Alpha, Rat	4	1	1	1

Clustered By Gene (0)

Clustered By Organism (2)

Code	Description	Substances	Purchasable	Natural	In Man
PPARA-1-E	Peroxisome Proliferator-activated Receptor Alpha (cluster #1 Of 3), Eukaryotic	1,437	20	16	26
PPARA-2-E	Peroxisome Proliferator-activated Receptor Alpha (cluster #2 Of 3), Eukaryotic	12	2	2	0
PPARA-3-E	Peroxisome Proliferator-activated Receptor Alpha (cluster #3 Of 3), Eukaryotic	2	1	0	0

Uniprot	Swissprot	Chembl	Description	Number Shared
PPARG_HUMAN	P37231	CHEMBL235	Peroxisome Proliferator-activated Receptor Gamma, Human	1843
PPARD_HUMAN	Q03181	CHEMBL3979	Peroxisome Proliferator-activated Receptor Delta, Human	902
PPARG_MOUSE	P37238	CHEMBL2459	Peroxisome Proliferator-activated Receptor Gamma, Mouse	127
PPARA_MOUSE	P23204	CHEMBL2128	Peroxisome Proliferator-activated Receptor Alpha, Mouse	78
PPARG_RAT	O88275	CHEMBL4797	Peroxisome Proliferator-activated Receptor Gamma, Rat	56
PPARA_CANFA	Q95N78	CHEMBL2847	Peroxisome Proliferator-activated Receptor Alpha, Canine	37
PPARD_MOUSE	P35396	CHEMBL2458	Peroxisome Proliferator-activated Receptor Delta, Mouse	29
NR1H2_HUMAN	P55055	CHEMBL4093	LXR-beta, Human	19
NR1H3_HUMAN	Q13133	CHEMBL2808	LXR-alpha, Human	19
Z80169	Z80169	CHEMBL614039	Huh-7 (Hepatocellular Carcinoma)	12
PPARA_RAT	P37230	CHEMBL2129	Peroxisome Proliferator-activated Receptor Alpha, Rat	9
KCNH2_HUMAN	Q12809	CHEMBL240	HERG, Human	8
AOFB_HUMAN	P27338	CHEMBL2039	Monoamine Oxidase B, Human	4
Z80106	Z80106	CHEMBL614563	COS-1 (Kidney Cells)	4
Z80548	Z80548	CHEMBL614245	THP-1 (Acute Monocytic Leukemia Cells)	4
Z81135	Z81135	CHEMBL614793	L6 (Skeletal Muscle Myoblast Cells)	4
Z80006	Z80006	CHEMBL614510	3T3-L1 (Fibroblast Cells)	3
FABPL_RAT	P02692	CHEMBL5738	Fatty Acid-binding Protein, Liver, Rat	2
RARG_HUMAN	P13631	CHEMBL2003	Retinoic Acid Receptor Gamma, Human	2
RXRA_HUMAN	P19793	CHEMBL2061	Retinoid X Receptor Alpha, Human	2
RXRA_RAT	Q05343	CHEMBL4431	Retinoid X Receptor Alpha, Rat	2
Z80561	Z80561	CHEMBL615023	U2OS (Osteosarcoma Cells)	2
Z81117	Z81117	CHEMBL613995	Keratinocytes (Keratinocytes)	2
CNR1_HUMAN	P21554	CHEMBL218	Cannabinoid CB1 Receptor, Human	1
CNR1_RAT	P20272	CHEMBL3571	Cannabinoid CB1 Receptor, Rat	1
FABPI_HUMAN	P12104	CHEMBL4879	Fatty Acid Binding Protein Intestinal, Human	1
Q7TNH1_MESAU	Q7TNH1	CHEMBL1075150	Peroxisome Proliferator Activated Receptor Alpha, Mesau	1
Z50425	Z50425	CHEMBL364	Plasmodium Falciparum	1
Z80178	Z80178	CHEMBL614040	J774.A1 (Macrophage Cells)	1
Z81020	Z81020	CHEMBL395	HepG2 (Hepatoblastoma Cells)	1
Z81244	Z81244	CHEMBL614123	J774 (Macrophage Cells)	1