| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 4 | 1 | 1 | 1 |
| Binding ≤ 1μM | 1 | 0 | 0 | 0 |
| Functional ≤ 10μM | 83 | 1 | 1 | 1 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_198613 | Activation of gene expression by SREBF (SREBP) | Rattus norvegicus |
| REACT_196405 | BMAL1:CLOCK,NPAS2 activates circadian gene expression | Rattus norvegicus |
| REACT_257889 | Circadian Clock | Rattus norvegicus |
| REACT_242509 | Nuclear Receptor transcription pathway | Rattus norvegicus |
| REACT_196408 | PPARA activates gene expression | Rattus norvegicus |
| REACT_245846 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp | Rattus norvegicus |
| REACT_196852 | REV-ERBA represses gene expression | Rattus norvegicus |
| REACT_196856 | RORA activates circadian gene expression | Rattus norvegicus |
| REACT_216049 | Transcriptional activation of mitochondrial biogenesis | Rattus norvegicus |
| REACT_260360 | Transcriptional regulation of white adipocyte differentiation | Rattus norvegicus |
| REACT_198793 | YAP1- and WWTR1 (TAZ)-stimulated gene expression | Rattus norvegicus |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| PPARA_CANFA | Q95N78 | CHEMBL2847 | Peroxisome Proliferator-activated Receptor Alpha, Canine | 35 | 0 | 0 | 0 |
| PPARA_HUMAN | Q07869 | CHEMBL239 | Peroxisome Proliferator-activated Receptor Alpha, Human | 1,414 | 22 | 16 | 24 |
| PPARA_MOUSE | P23204 | CHEMBL2128 | Peroxisome Proliferator-activated Receptor Alpha, Mouse | 32 | 5 | 4 | 6 |
| Code | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|
| PPARA-1-E | Peroxisome Proliferator-activated Receptor Alpha (cluster #1 Of 3), Eukaryotic | 1,437 | 20 | 16 | 26 |
| PPARA-2-E | Peroxisome Proliferator-activated Receptor Alpha (cluster #2 Of 3), Eukaryotic | 12 | 2 | 2 | 0 |
| PPARA-3-E | Peroxisome Proliferator-activated Receptor Alpha (cluster #3 Of 3), Eukaryotic | 2 | 1 | 0 | 0 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| PPARA_HUMAN | Q07869 | CHEMBL239 | Peroxisome Proliferator-activated Receptor Alpha, Human | 9 |
| PPARD_HUMAN | Q03181 | CHEMBL3979 | Peroxisome Proliferator-activated Receptor Delta, Human | 8 |
| PPARG_HUMAN | P37231 | CHEMBL235 | Peroxisome Proliferator-activated Receptor Gamma, Human | 8 |
| PPARA_MOUSE | P23204 | CHEMBL2128 | Peroxisome Proliferator-activated Receptor Alpha, Mouse | 3 |
| PPARD_MOUSE | P35396 | CHEMBL2458 | Peroxisome Proliferator-activated Receptor Delta, Mouse | 1 |
| PPARG_MOUSE | P37238 | CHEMBL2459 | Peroxisome Proliferator-activated Receptor Gamma, Mouse | 1 |