UCSF

Steroid 5-alpha-reductase 1, Human (1,054 Compounds)

Swissprot:
S5A1_HUMAN
Stitch:
S5A1_HUMAN
UniProt:
P18405
ChEMBL:
CHEMBL1787
Reactome:
REACT_11059
PDB:
SRD5A1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 1,054 14 6 6
Binding ≤ 1μM 907 11 5 5
Functional ≤ 10μM 5 1 1 1

Reactome Network (1)

Reactome ID Description Species
REACT_11059 Androgen biosynthesis Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
3BHS1_HUMAN P14060 CHEMBL1958 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type I, Human 369
3BHS2_HUMAN P26439 CHEMBL3670 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type II, Human 359
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 32
DHB3_HUMAN P37058 CHEMBL4234 Estradiol 17-beta-dehydrogenase 3, Human 1
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 835
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
S5A1_RAT P24008 CHEMBL3422 Steroid 5-alpha-reductase 1, Rat 544 27 5 5
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 970 12 5 6

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
S5A1-1-E Steroid 5-alpha-reductase 1 (cluster #1 Of 2), Eukaryotic 823 27 7 9
S5A1-2-E Steroid 5-alpha-reductase 1 (cluster #2 Of 2), Eukaryotic 759 16 2 1
Uniprot Swissprot Chembl Description Number Shared
S5A2_HUMAN P31213 CHEMBL1856 Steroid 5-alpha-reductase 2, Human 835
3BHS1_HUMAN P14060 CHEMBL1958 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type I, Human 369
3BHS2_HUMAN P26439 CHEMBL3670 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type II, Human 359
3BHS7_HUMAN Q9H2F3 CHEMBL3600 3-beta-hydroxysteroid Dehydrogenase Type VII, Human 116
S5A1_RAT P24008 CHEMBL3422 Steroid 5-alpha-reductase 1, Rat 87
S5A2_RAT P31214 CHEMBL5099 Steroid 5-alpha-reductase 2, Rat 86
CP17A_HUMAN P05093 CHEMBL3522 Cytochrome P450 17A1, Human 28
CP17A_RAT P11715 CHEMBL4430 Cytochrome P450 17A1, Rat 28
3BHS2_RAT P22072 CHEMBL4821 3-beta-hydroxysteroid Dehydrogenase/delta 5-->4-isomerase Type II, Rat 13
3BHS5_RAT P27364 CHEMBL4490 3-beta-hydroxysteroid Dehydrogenase Type III, Rat 13
CP19A_HUMAN P11511 CHEMBL1978 Cytochrome P450 19A1, Human 5
DHB3_HUMAN P37058 CHEMBL4234 Estradiol 17-beta-dehydrogenase 3, Human 1
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 1
Z80125 Z80125 CHEMBL613508 DU-145 (Prostate Carcinoma) 1

Most Common Rings