UCSF

Dopamine Transporter, Rat (2,890 Compounds)

Swissprot:
SC6A3_RAT
Stitch:
SC6A3_RAT
UniProt:
P23977
ChEMBL:
CHEMBL338
Reactome:
REACT_244757
REACT_244063
PDB:
Slc6a3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 2,890 133 48 52
Binding ≤ 1μM 2,435 83 29 35
Functional ≤ 10μM 609 32 21 25

Reactome Network (2)

Uniprot Swissprot Chembl Description Number Shared
VMAT2_RAT Q01827 CHEMBL4828 Synaptic Vesicular Amine Transporter, Rat 19
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
SC6A3_BOVIN P27922 CHEMBL2986 Dopamine Transporter, Bovin 51 1 1 1
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 2,208 143 41 50
SC6A3_MACFA Q9GJT6 CHEMBL5032 Dopamine Transporter, Macfa 25 0 0 0
SC6A3_MOUSE Q61327 CHEMBL2799 Dopamine Transporter, Mouse 55 10 6 7
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
SC6A1_RAT P23978 CHEMBL4054 GABA Transporter 1, Rat 105 11 7 3
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 3,586 155 40 53
SC6A5_RAT P58295 CHEMBL3195 Glycine Transporter 2, Rat 12 2 0 0
SC6A8_RAT P28570 CHEMBL3814 Creatine Transporter, Rat 2 0 0 0
SC6A9_RAT P28572 CHEMBL4556 Glycine Transporter 1, Rat 27 2 0 0

Clustered By Gene (0)

Clustered By Organism (2)

Code Description Substances Purchasable Natural In Man
SC6A3-1-E Dopamine Transporter (cluster #1 Of 3), Eukaryotic 4,670 193 44 54
SC6A3-2-E Dopamine Transporter (cluster #2 Of 3), Eukaryotic 280 40 20 13
SC6A3-3-E Dopamine Transporter (cluster #3 Of 3), Eukaryotic 241 38 15 21
Uniprot Swissprot Chembl Description Number Shared
SC6A4_RAT P31652 CHEMBL313 Serotonin Transporter, Rat 2109
Q9WTR4_RAT Q9WTR4 CHEMBL304 Norepinephrine Transporter, Rat 1445
SC6A3_HUMAN Q01959 CHEMBL238 Dopamine Transporter, Human 195
SC6A4_HUMAN P31645 CHEMBL228 Serotonin Transporter, Human 181
SC6A2_HUMAN P23975 CHEMBL222 Norepinephrine Transporter, Human 142
ACM1_RAT P08482 CHEMBL276 Muscarinic Acetylcholine Receptor M1, Rat 141
Q63380_RAT Q63380 CHEMBL6184 Transporter, Rat 139
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 130
SGMR1_HUMAN Q99720 CHEMBL287 Sigma Opioid Receptor, Human 85
DRD2_RAT P61169 CHEMBL339 Dopamine D2 Receptor, Rat 49
Z100491 Z100491 CHEMBL613288 Sigma 2 Receptor 33
DRD3_RAT P19020 CHEMBL3138 Dopamine D3 Receptor, Rat 32
SGMR1_RAT Q9R0C9 CHEMBL3602 Sigma Opioid Receptor, Rat 30
DRD1_RAT P18901 CHEMBL265 Dopamine D1 Receptor, Rat 27
SGMR1_CAVPO Q60492 CHEMBL4153 Sigma-1 Receptor, Guinea Pig 27
5HT2A_RAT P14842 CHEMBL322 Serotonin 2a (5-HT2a) Receptor, Rat 23
5HT2B_RAT P30994 CHEMBL323 Serotonin 2b (5-HT2b) Receptor, Rat 23
5HT2C_RAT P08909 CHEMBL324 Serotonin 2c (5-HT2c) Receptor, Rat 23
ACM2_RAT P10980 CHEMBL309 Muscarinic Acetylcholine Receptor M2, Rat 23
Z104304 Z104304 CHEMBL1907610 Adrenergic Receptor Alpha-1 23
VMAT2_RAT Q01827 CHEMBL4828 Synaptic Vesicular Amine Transporter, Rat 19
ADRB1_RAT P18090 CHEMBL3252 Beta-1 Adrenergic Receptor, Rat 18
DRD3_HUMAN P35462 CHEMBL234 Dopamine D3 Receptor, Human 18
ADRB3_RAT P26255 CHEMBL4031 Beta-3 Adrenergic Receptor, Rat 17
SC6A3_MOUSE Q61327 CHEMBL2799 Dopamine Transporter, Mouse 17
ADRB2_CANFA P54833 CHEMBL2289 Beta-2 Adrenergic Receptor, Canine 16
DRD4_RAT P30729 CHEMBL3361 Dopamine D4 Receptor, Rat 15
DRD5_RAT P25115 CHEMBL2281 Dopamine D5 Receptor, Rat 15
SC6A2_MOUSE O55192 CHEMBL2370 Norepinephrine Transporter, Mouse 15
ACM1_HUMAN P11229 CHEMBL216 Muscarinic Acetylcholine Receptor M1, Human 14
VACHT_HUMAN Q16572 CHEMBL4767 Vesicular Acetylcholine Transporter, Human 14
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 12
Z50425 Z50425 CHEMBL364 Plasmodium Falciparum 12
5HT1A_RAT P19327 CHEMBL273 Serotonin 1a (5-HT1a) Receptor, Rat 11
DRD2_HUMAN P14416 CHEMBL217 Dopamine D2 Receptor, Human 11
OPRM_RAT P33535 CHEMBL270 Mu Opioid Receptor, Rat 11
DRD4_HUMAN P21917 CHEMBL219 Dopamine D4 Receptor, Human 10
5HT1B_RAT P28564 CHEMBL3459 Serotonin 1b (5-HT1b) Receptor, Rat 9
5HT1D_RAT P28565 CHEMBL5450 Serotonin 1d (5-HT1d) Receptor, Rat 9
5HT1F_RAT P30940 CHEMBL4646 Serotonin 1f (5-HT1f) Receptor, Rat 9
SC6A3_BOVIN P27922 CHEMBL2986 Dopamine Transporter, Bovin 8
ADA2A_RAT P22909 CHEMBL327 Alpha-2a Adrenergic Receptor, Rat 7
ADA2B_RAT P19328 CHEMBL266 Alpha-2b Adrenergic Receptor, Rat 7
ADA2C_RAT P22086 CHEMBL314 Alpha-2c Adrenergic Receptor, Rat 7
OPRM_HUMAN P35372 CHEMBL233 Mu Opioid Receptor, Human 7
SC6A4_MOUSE Q60857 CHEMBL4642 Serotonin Transporter, Mouse 6
OPRK_RAT P34975 CHEMBL3614 Kappa Opioid Receptor, Rat 5
5HT2A_HUMAN P28223 CHEMBL224 Serotonin 2a (5-HT2a) Receptor, Human 4
ACHA7_RAT Q05941 CHEMBL4980 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat 4
ADA2A_HUMAN P08913 CHEMBL1867 Alpha-2a Adrenergic Receptor, Human 4
ADA2B_HUMAN P18089 CHEMBL1942 Alpha-2b Adrenergic Receptor, Human 4
ADA2C_HUMAN P18825 CHEMBL1916 Alpha-2c Adrenergic Receptor, Human 4
Z104290 Z104290 CHEMBL1907596 Neuronal Acetylcholine Receptor; Alpha4/beta2 4
Z80936 Z80936 CHEMBL614818 HEK293 (Embryonic Kidney Fibroblasts) 4
5HT2C_HUMAN P28335 CHEMBL225 Serotonin 2c (5-HT2c) Receptor, Human 3
5HT4R_RAT Q62758 CHEMBL4317 Serotonin 4 (5-HT4) Receptor, Rat 3
ACH10_RAT Q9JLB5 CHEMBL3461 Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Rat 3
ACHA2_RAT P12389 CHEMBL2584 Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Rat 3
ACHA3_RAT P04757 CHEMBL3818 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Rat 3
ACHA4_RAT P09483 CHEMBL307 Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat 3
ACHA5_RAT P20420 CHEMBL4960 Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Rat 3
ACHA6_RAT P43143 CHEMBL4747 Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Rat 3
ACHA9_RAT P43144 CHEMBL2585 Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Rat 3
ACHA_RAT P25108 CHEMBL3599 Acetylcholine Receptor Protein Alpha Chain, Rat 3
ACHB2_RAT P12390 CHEMBL3001 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Rat 3
ACHB3_RAT P12391 CHEMBL4568 Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Rat 3
ACHB4_RAT P12392 CHEMBL2658 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Rat 3
ACHB_RAT P25109 CHEMBL2666 Acetylcholine Receptor Protein Beta Chain, Rat 3
ADA1A_RAT P43140 CHEMBL319 Alpha-1a Adrenergic Receptor, Rat 3
HRH1_HUMAN P35367 CHEMBL231 Histamine H1 Receptor, Human 3
OPRK_HUMAN P41145 CHEMBL237 Kappa Opioid Receptor, Human 3
5HT1A_HUMAN P08908 CHEMBL214 Serotonin 1a (5-HT1a) Receptor, Human 2
5HT2B_HUMAN P41595 CHEMBL1833 Serotonin 2b (5-HT2b) Receptor, Human 2
5HT3A_RAT P35563 CHEMBL2411 Serotonin 3a (5-HT3a) Receptor, Rat 2
5HT3B_RAT Q9JJ16 CHEMBL3458 Serotonin 3b (5-HT3b) Receptor, Rat 2
ACES_HUMAN P22303 CHEMBL220 Acetylcholinesterase, Human 2
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 2
ACHB2_HUMAN P17787 CHEMBL1883 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human 2
ADA1B_RAT P15823 CHEMBL315 Alpha-1b Adrenergic Receptor, Rat 2
ADCY1_HUMAN Q08828 CHEMBL2899 Brain Adenylate Cyclase 1, Human 2
ADCY2_HUMAN Q08462 CHEMBL3760 Adenylate Cyclase Type II, Human 2
ADCY8_HUMAN P40145 CHEMBL2960 Adenylate Cyclase Type VIII, Human 2
DRD1_HUMAN P21728 CHEMBL2056 Dopamine D1 Receptor, Human 2
DRD2_BOVIN P20288 CHEMBL3998 Dopamine D2 Receptor, Bovin 2
DRD5_HUMAN P21918 CHEMBL1850 Dopamine D5 Receptor, Human 2
HRH2_HUMAN P25021 CHEMBL1941 Histamine H2 Receptor, Human 2
HRH3_HUMAN Q9Y5N1 CHEMBL264 Histamine H3 Receptor, Human 2
PCP_HUMAN P42785 CHEMBL2335 Lysosomal Pro-X Carboxypeptidase, Human 2
SC6A3_MACFA Q9GJT6 CHEMBL5032 Dopamine Transporter, Macfa 2
VMAT2_HUMAN Q05940 CHEMBL1893 Synaptic Vesicular Amine Transporter, Human 2
Z100251 Z100251 CHEMBL612442 Monoclonal Antibody (mAb) 2E2 2
Z104288 Z104288 CHEMBL1907594 Neuronal Acetylcholine Receptor; Alpha3/beta4 2
Z104302 Z104302 CHEMBL1907608 Glutamate NMDA Receptor 2
5HT1B_HUMAN P28222 CHEMBL1898 Serotonin 1b (5-HT1b) Receptor, Human 1
5HT1D_HUMAN P28221 CHEMBL1983 Serotonin 1d (5-HT1d) Receptor, Human 1
5HT1E_HUMAN P28566 CHEMBL2182 Serotonin 1e (5-HT1e) Receptor, Human 1
5HT1F_HUMAN P30939 CHEMBL1805 Serotonin 1f (5-HT1f) Receptor, Human 1
5HT2A_MOUSE P35363 CHEMBL5377 Serotonin 2a (5-HT2a) Receptor, Mouse 1
5HT2B_MOUSE Q02152 CHEMBL2583 Serotonin 2b (5-HT2b) Receptor, Mouse 1
5HT2C_MOUSE P34968 CHEMBL3006 Serotonin 2c (5-HT2c) Receptor, Mouse 1
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 1
5HT3B_HUMAN O95264 CHEMBL3895 Serotonin 3b (5-HT3b) Receptor, Human 1
5HT3C_HUMAN Q8WXA8 CHEMBL4795 Serotonin 3c (5-HT3c) Receptor, Human 1
5HT3D_HUMAN Q70Z44 CHEMBL4673 Serotonin 3d (5-HT3d) Receptor, Human 1
5HT5A_RAT P35364 CHEMBL4655 Serotonin 5a (5-HT5a) Receptor, Rat 1
5HT5B_RAT P35365 CHEMBL2619 Serotonin 5b (5-HT5b) Receptor, Rat 1
5HT6R_RAT P31388 CHEMBL3372 Serotonin 6 (5-HT6) Receptor, Rat 1
5HT7R_RAT P32305 CHEMBL3223 Serotonin 7 (5-HT7) Receptor, Rat 1
AA3R_HUMAN P33765 CHEMBL256 Adenosine A3 Receptor, Human 1
ACM2_HUMAN P08172 CHEMBL211 Muscarinic Acetylcholine Receptor M2, Human 1
ADA1A_HUMAN P35348 CHEMBL229 Alpha-1a Adrenergic Receptor, Human 1
ADA1D_RAT P23944 CHEMBL326 Alpha-1d Adrenergic Receptor, Rat 1
ADCY2_RAT P26769 CHEMBL2958 Adenylate Cyclase Type II, Rat 1
ADCY3_RAT P21932 CHEMBL4864 Adenylate Cyclase Type III, Rat 1
ADCY4_RAT P26770 CHEMBL2879 Adenylate Cyclase Type IV, Rat 1
ADCY5_RAT Q04400 CHEMBL2880 Adenylate Cyclase Type V, Rat 1
ADCY6_RAT Q03343 CHEMBL2975 Adenylate Cyclase Type VI, Rat 1
ADCY8_RAT P40146 CHEMBL3082 Adenylate Cyclase Type VIII, Rat 1
ADRB2_RAT P10608 CHEMBL3754 Beta-2 Adrenergic Receptor, Rat 1
D4A3N4_RAT D4A3N4 CHEMBL2679 Brain Adenylate Cyclase 1, Rat 1
DRD1_BOVIN Q95136 CHEMBL2967 Dopamine D1 Receptor, Bovin 1
EBP_CAVPO Q60490 CHEMBL5525 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Guinea Pig 1
EBP_HUMAN Q15125 CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase, Human 1
G3P_HUMAN P04406 CHEMBL2284 Glyceraldehyde-3-phosphate Dehydrogenase Liver, Human 1
HRH1_RAT P31390 CHEMBL4701 Histamine H1 Receptor, Rat 1
MTR1A_HUMAN P48039 CHEMBL1945 Melatonin Receptor 1A, Human 1
MTR1B_HUMAN P49286 CHEMBL1946 Melatonin Receptor 1B, Human 1
NK1R_HUMAN P25103 CHEMBL249 Neurokinin 1 Receptor, Human 1
NORA_STAAU P0A0J7 CHEMBL5114 Quinolone Resistance Protein NorA, Staau 1
OPRD_RAT P33533 CHEMBL269 Delta Opioid Receptor, Rat 1
OPRK_CAVPO P41144 CHEMBL3952 Kappa Opioid Receptor, Guinea Pig 1
OPRM_MOUSE P42866 CHEMBL2858 Mu Opioid Receptor, Mouse 1
PDE4A_RAT P54748 CHEMBL4964 Phosphodiesterase 4A, Rat 1
PDE4B_RAT P14646 CHEMBL3382 Phosphodiesterase 4B, Rat 1
PDE4C_RAT P14644 CHEMBL4562 Phosphodiesterase 4C, Rat 1
PDE4D_RAT P14270 CHEMBL2712 Phosphodiesterase 4D, Rat 1
PDE5A_HUMAN O76074 CHEMBL1827 Phosphodiesterase 5A, Human 1
Q8CFM9_RAT Q8CFM9 CHEMBL3940 Adenylate Cyclase Type VII, Rat 1
SCN1A_HUMAN P35498 CHEMBL1845 Sodium Channel Protein Type I Alpha Subunit, Human 1
SCN2A_HUMAN Q99250 CHEMBL4187 Sodium Channel Protein Type II Alpha Subunit, Human 1
SCN3A_HUMAN Q9NY46 CHEMBL5163 Sodium Channel Protein Type III Alpha Subunit, Human 1
SCN8A_HUMAN Q9UQD0 CHEMBL5202 Sodium Channel Protein Type VIII Alpha Subunit, Human 1
SGMR1_MOUSE O55242 CHEMBL3465 Sigma Opioid Receptor, Mouse 1
VACHT_RAT Q62666 CHEMBL2125 Vesicular Acetylcholine Transporter, Rat 1
VMAT1_RAT Q01818 CHEMBL2702 Vesicular Amine Transporter 1, Rat 1
Z104303 Z104303 CHEMBL1907609 Muscarinic Acetylcholine Receptor 1
Z50466 Z50466 CHEMBL368 Trypanosoma Cruzi 1
Z50590 Z50590 CHEMBL613488 Sus Scrofa 1
Z50591 Z50591 CHEMBL613489 Bos Taurus 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1
Z50607 Z50607 CHEMBL378 Human Immunodeficiency Virus 1 1
Z50652 Z50652 CHEMBL613740 Influenza A Virus 1
Z50796 Z50796 CHEMBL614874 Monkey 1
Z80150 Z80150 CHEMBL614576 H9c2 (Cardiomyoblast Cells) 1
Z80418 Z80418 CHEMBL612557 RAW264.7 (Monocytic-macrophage Leukemia Cells) 1
Z80420 Z80420 CHEMBL614632 RBL-2H3 (Basophilic Leukemia Cells) 1