Physical Representations
|
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
|
Ref
Reference (pH 7)
|
3.88 |
-2.42 |
-12.54 |
2 |
5 |
0 |
67 |
323.377 |
3 |
↓
|
Clustered Target Annotations
| Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
PLCG2-2-E |
Phospholipase C-gamma-2 (cluster #2 Of 2), Eukaryotic |
Eukaryotes |
5000 |
0.32 |
Binding ≤ 10μM
|
ChEMBL Target Annotations
| Uniprot |
Swissprot |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
PLCG2_HUMAN |
P16885
|
Phospholipase C-gamma-2, Human |
5000 |
0.32 |
Binding ≤ 10μM
|
Reactome Annotations from Targets (via Uniprot)
| Description |
Species |
|
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge |
|
|
DAP12 signaling |
|
|
FCERI mediated Ca+2 mobilization |
|
|
FCERI mediated MAPK activation |
|
|
GPVI-mediated activation cascade |
|
|
Role of phospholipids in phagocytosis |
|
|
Synthesis of IP3 and IP4 in the cytosol |
|
|
Toll Like Receptor 4 (TLR4) Cascade |
|
No pre-computed analogs available. Try a structural similarity search.
