|
Abacavir metabolism |
|
|
Abacavir transmembrane transport |
|
|
ABC-family proteins mediated transport |
|
|
ABCA transporters in lipid homeostasis |
|
|
Acetylcholine Neurotransmitter Release Cycle |
|
|
Acetylcholine regulates insulin secretion |
|
|
Activated point mutants of FGFR2 |
|
|
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation |
|
|
Activated TAK1 mediates p38 MAP kinase phosphorylation |
|
|
activated TAK1 mediates p38 MAPK activation |
|
|
Activation of ATR in response to replication stress |
|
|
Activation of BAD and translocation to mitochondria |
|
|
Activation of CaMK IV |
|
|
Activation of caspases through apoptosome-mediated cleavage |
|
|
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
|
|
Activation of NF-kappaB in B cells |
|
|
Activation of NIMA Kinases NEK9, NEK6, NEK7 |
|
|
Activation of PKB |
|
|
Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
|
|
Activation of RAS in B cells |
|
|
Activation of the AP-1 family of transcription factors |
|
|
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub |
|
|
Activation of the pre-replicative complex |
|
|
ADP signalling through P2Y purinoceptor 1 |
|
|
ADP signalling through P2Y purinoceptor 12 |
|
|
AKT phosphorylates targets in the cytosol |
|
|
AKT phosphorylates targets in the nucleus |
|
|
AKT-mediated inactivation of FOXO1A |
|
|
alpha-linolenic acid (ALA) metabolism |
|
|
Amino acid synthesis and interconversion (transamination) |
|
|
AMPK inhibits chREBP transcriptional activation activity |
|
|
Antigen activates B Cell Receptor (BCR) leading to generation of second messenge |
|
|
Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
|
|
ARMS-mediated activation |
|
|
Association of TriC/CCT with target proteins during biosynthesis |
|
|
Astrocytic Glutamate-Glutamine Uptake And Metabolism |
|
|
Asymmetric localization of PCP proteins |
|
|
ATM mediated phosphorylation of repair proteins |
|
|
ATM mediated response to DNA double-strand break |
|
|
Autodegradation of the E3 ubiquitin ligase COP1 |
|
|
Beta-catenin phosphorylation cascade |
|
|
betaKlotho-mediated ligand binding |
|
|
Branched-chain amino acid catabolism |
|
|
Butyrate Response Factor 1 (BRF1) destabilizes mRNA |
|
|
c-src mediated regulation of Cx43 function and closure of gap junctions |
|
|
Ca2+ pathway |
|
|
Calmodulin induced events |
|
|
CaMK IV-mediated phosphorylation of CREB |
|
|
CD28 co-stimulation |
|
|
CD28 dependent PI3K/Akt signaling |
|
|
CD28 dependent Vav1 pathway |
|
|
CDK-mediated phosphorylation and removal of Cdc6 |
|
|
CDO in myogenesis |
|
|
Chk1-controlled and DNA-damage induced centrosome duplication |
|
|
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
|
|
CHL1 interactions |
|
|
Cholesterol biosynthesis |
|
|
Chorismate via Shikimate Pathway |
|
|
Citric acid cycle (TCA cycle) |
|
|
Clearance of Nuclear Envelope Membranes from Chromatin |
|
|
Cobalamin (Cbl, vitamin B12) transport and metabolism |
|
|
Coenzyme A biosynthesis |
|
|
Condensation of Prometaphase Chromosomes |
|
|
Condensation of Prophase Chromosomes |
|
|
Constitutive PI3K/AKT Signaling in Cancer |
|
|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
|
|
Constitutive Signaling by NOTCH1 PEST Domain Mutants |
|
|
Creatine metabolism |
|
|
CREB phosphorylation |
|
|
CREB phosphorylation through the activation of Adenylate Cyclase |
|
|
CREB phosphorylation through the activation of CaMKII |
|
|
CREB phosphorylation through the activation of CaMKK |
|
|
CREB phosphorylation through the activation of Ras |
|
|
CRMPs in Sema3A signaling |
|
|
CTLA4 inhibitory signaling |
|
|
Cyclin A/B1 associated events during G2/M transition |
|
|
Cyclin A:Cdk2-associated events at S phase entry |
|
|
Cyclin B2 mediated events |
|
|
Cyclin D associated events in G1 |
|
|
Cyclin E associated events during G1/S transition |
|
|
DAG and IP3 signaling |
|
|
DAP12 signaling |
|
|
DARPP-32 events |
|
|
DCC mediated attractive signaling |
|
|
De novo synthesis of IMP |
|
|
De novo synthesis of UMP |
|
|
deactivation of the beta-catenin transactivating complex |
|
|
Degradation of beta-catenin by the destruction complex |
|
|
Depolymerisation of the Nuclear Lamina |
|
|
Detoxification of Reactive Oxygen Species |
|
|
disassembly of the destruction complex and recruitment of AXIN to the membrane |
|
|
Disinhibition of SNARE formation |
|
|
DNA Damage/Telomere Stress Induced Senescence |
|
|
Dopamine Neurotransmitter Release Cycle |
|
|
Downregulation of ERBB2:ERBB3 signaling |
|
|
Downstream signal transduction |
|
|
Downstream TCR signaling |
|
|
DSCAM interactions |
|
|
Effects of PIP2 hydrolysis |
|
|
EGFR downregulation |
|
|
EGFR interacts with phospholipase C-gamma |
|
|
Endosomal Sorting Complex Required For Transport (ESCRT) |
|
|
eNOS activation |
|
|
EPH-ephrin mediated repulsion of cells |
|
|
EPH-Ephrin signaling |
|
|
EPHA-mediated growth cone collapse |
|
|
EPHB-mediated forward signaling |
|
|
Ephrin signaling |
|
|
ER-Phagosome pathway |
|
|
ERK/MAPK targets |
|
|
ERK1 activation |
|
|
ERK2 activation |
|
|
Factors involved in megakaryocyte development and platelet production |
|
|
Fanconi Anemia Pathway in DNA repair |
|
|
Fatty Acyl-CoA Biosynthesis |
|
|
Fc epsilon receptor (FCERI) signaling |
|
|
FCERI mediated Ca+2 mobilization |
|
|
FCERI mediated MAPK activation |
|
|
FCERI mediated NF-kB activation |
|
|
FCGR activation |
|
|
FGFR1b ligand binding and activation |
|
|
FGFR1c and Klotho ligand binding and activation |
|
|
FGFR1c ligand binding and activation |
|
|
FGFR2b ligand binding and activation |
|
|
FGFR2c ligand binding and activation |
|
|
FGFR3b ligand binding and activation |
|
|
FGFR3c ligand binding and activation |
|
|
FGFR4 ligand binding and activation |
|
|
Folding of actin by CCT/TriC |
|
|
Formation of apoptosome |
|
|
Formation of ATP by chemiosmotic coupling |
|
|
Formation of HIV-1 elongation complex containing HIV-1 Tat |
|
|
Formation of tubulin folding intermediates by CCT/TriC |
|
|
Frs2-mediated activation |
|
|
FRS2-mediated cascade |
|
|
Fructose catabolism |
|
|
G alpha (i) signalling events |
|
|
G alpha (q) signalling events |
|
|
G beta:gamma signalling through PI3Kgamma |
|
|
G0 and Early G1 |
|
|
G2 Phase |
|
|
G2/M DNA damage checkpoint |
|
|
G2/M DNA replication checkpoint |
|
|
GAB1 signalosome |
|
|
Galactose catabolism |
|
|
Gastrin-CREB signalling pathway via PKC and MAPK |
|
|
Generation of second messenger molecules |
|
|
Gluconeogenesis |
|
|
Glucose transport |
|
|
Glutathione synthesis and recycling |
|
|
Glycogen breakdown (glycogenolysis) |
|
|
Glycolysis |
|
|
Glycosphingolipid metabolism |
|
|
Golgi Associated Vesicle Biogenesis |
|
|
Golgi Cisternae Pericentriolar Stack Reorganization |
|
|
GPVI-mediated activation cascade |
|
|
Growth hormone receptor signaling |
|
|
HDL-mediated lipid transport |
|
|
Hedgehog ligand biogenesis |
|
|
Hh ligand biogenesis disease |
|
|
Homologous DNA pairing and strand exchange |
|
|
Homologous recombination repair of replication-dependent double-strand breaks |
|
|
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
|
|
HSF1-dependent transactivation |
|
|
HuR stabilizes mRNA |
|
|
Import of palmitoyl-CoA into the mitochondrial matrix |
|
|
Inactivation, recovery and regulation of the phototransduction cascade |
|
|
Inhibition of TSC complex formation by PKB |
|
|
Integrin alphaIIb beta3 signaling |
|
|
Interaction between L1 and Ankyrins |
|
|
Interferon alpha/beta signaling |
|
|
Interferon gamma signaling |
|
|
Interleukin receptor SHC signaling |
|
|
Interleukin-1 signaling |
|
|
Interleukin-2 signaling |
|
|
Interleukin-3, 5 and GM-CSF signaling |
|
|
Interleukin-6 signaling |
|
|
Interleukin-7 signaling |
|
|
Ion transport by P-type ATPases |
|
|
IRAK1 recruits IKK complex |
|
|
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
|
|
IRAK2 mediated activation of TAK1 complex |
|
|
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
|
|
IRE1alpha activates chaperones |
|
|
IRF3 mediated activation of type 1 IFN |
|
|
IRF3-mediated induction of type I IFN |
|
|
Iron uptake and transport |
|
|
IRS activation |
|
|
IRS-related events triggered by IGF1R |
|
|
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human |
|
|
Kinesins |
|
|
KSRP destabilizes mRNA |
|
|
L1CAM interactions |
|
|
Linoleic acid (LA) metabolism |
|
|
Loss of Nlp from mitotic centrosomes |
|
|
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production |
|
|
Lysosome Vesicle Biogenesis |
|
|
MASTL Facilitates Mitotic Progression |
|
|
Meiotic synapsis |
|
|
Metabolism of folate and pterines |
|
|
Metabolism of nucleotides |
|
|
MHC class II antigen presentation |
|
|
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
|
|
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
|
|
Mitochondrial ABC transporters |
|
|
Mitochondrial protein import |
|
|
MyD88 cascade initiated on plasma membrane |
|
|
MyD88 dependent cascade initiated on endosome |
|
|
MyD88-dependent cascade initiated on endosome membrane |
|
|
MyD88:Mal cascade initiated on plasma membrane |
|
|
MyD88:TIRAP-dependent cascade initiated on plasma membrane |
|
|
NCAM signaling for neurite out-growth |
|
|
Negative regulation of FGFR signaling |
|
|
Nephrin interactions |
|
|
Netrin mediated repulsion signals |
|
|
Netrin-1 signaling |
|
|
Neurofascin interactions |
|
|
NF-kB is activated and signals survival |
|
|
NFkB and MAPK activation mediated by TRAF6 |
|
|
NFkB activation mediated by RIP1 complexed with activated TLR3 |
|
|
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation |
|
|
Nicotinate metabolism |
|
|
NOD1/2 Signaling Pathway |
|
|
Non-homologous end joining (NHEJ) |
|
|
Nonhomologous End-joining (NHEJ) |
|
|
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
|
|
Norepinephrine Neurotransmitter Release Cycle |
|
|
NOTCH1 Intracellular Domain Regulates Transcription |
|
|
NRAGE signals death through JNK |
|
|
NRIF signals cell death from the nucleus |
|
|
Nuclear Pore Complex (NPC) Disassembly |
|
|
Oncogene Induced Senescence |
|
|
Orc1 removal from chromatin |
|
|
Oxidative Stress Induced Senescence |
|
|
p130Cas linkage to MAPK signaling for integrins |
|
|
P2Y receptors |
|
|
p38MAPK events |
|
|
p53-Independent DNA Damage Response |
|
|
p75NTR recruits signalling complexes |
|
|
PCP/CE pathway |
|
|
PD-1 signaling |
|
|
PDE3B signalling |
|
|
PECAM1 interactions |
|
|
PERK regulates gene expression |
|
|
phospho-PLA2 pathway |
|
|
Phospholipase C-mediated cascade |
|
|
Phosphorylation of CD3 and TCR zeta chains |
|
|
Phosphorylation of Emi1 |
|
|
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 |
|
|
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 com |
|
|
PI-3K cascade |
|
|
PI3K Cascade |
|
|
PI3K events in ERBB2 signaling |
|
|
PI3K events in ERBB4 signaling |
|
|
PI3K/AKT activation |
|
|
PIP3 activates AKT signaling |
|
|
PKA-mediated phosphorylation of CREB |
|
|
PKA-mediated phosphorylation of key metabolic factors |
|
|
Platelet degranulation |
|
|
Platelet sensitization by LDL |
|
|
PLCG1 events in ERBB2 signaling |
|
|
Polo-like kinase mediated events |
|
|
Polymerase switching |
|
|
Polymerase switching on the C-strand of the telomere |
|
|
Prefoldin mediated transfer of substrate to CCT/TriC |
|
|
Prolactin receptor signaling |
|
|
Propionyl-CoA catabolism |
|
|
Purine catabolism |
|
|
Purine ribonucleoside monophosphate biosynthesis |
|
|
Purine salvage |
|
|
Pyrimidine biosynthesis |
|
|
Pyrimidine catabolism |
|
|
Pyrimidine salvage reactions |
|
|
RAF activation |
|
|
RAF phosphorylates MEK |
|
|
Rap1 signalling |
|
|
Recruitment of NuMA to mitotic centrosomes |
|
|
Recycling of bile acids and salts |
|
|
Recycling pathway of L1 |
|
|
Regulation of actin dynamics for phagocytic cup formation |
|
|
Regulation of AMPK activity via LKB1 |
|
|
Regulation of APC/C activators between G1/S and early anaphase |
|
|
Regulation of HSF1-mediated heat shock response |
|
|
Regulation of insulin secretion |
|
|
Regulation of KIT signaling |
|
|
Regulation of PLK1 Activity at G2/M Transition |
|
|
Regulation of pyruvate dehydrogenase (PDH) complex |
|
|
Regulation of Rheb GTPase activity by AMPK |
|
|
Regulation of signaling by CBL |
|
|
Release of eIF4E |
|
|
Resolution of Sister Chromatid Cohesion |
|
|
Ribosomal scanning and start codon recognition |
|
|
RIP-mediated NFkB activation via ZBP1 |
|
|
RMTs methylate histone arginines |
|
|
RNA Polymerase II Transcription Initiation And Promoter Clearance |
|
|
Role of Abl in Robo-Slit signaling |
|
|
Role of DCC in regulating apoptosis |
|
|
Role of LAT2/NTAL/LAB on calcium mobilization |
|
|
Role of phospholipids in phagocytosis |
|
|
Role of second messengers in netrin-1 signaling |
|
|
RSK activation |
|
|
S6K1 signalling |
|
|
S6K1-mediated signalling |
|
|
SCF(Skp2)-mediated degradation of p27/p21 |
|
|
Sema3A PAK dependent Axon repulsion |
|
|
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
|
|
Sema4D induced cell migration and growth-cone collapse |
|
|
Sema4D mediated inhibition of cell attachment and migration |
|
|
Senescence-Associated Secretory Phenotype (SASP) |
|
|
Serotonin Neurotransmitter Release Cycle |
|
|
SHC activation |
|
|
SHC-mediated cascade |
|
|
SHC-related events triggered by IGF1R |
|
|
SHC1 events in EGFR signaling |
|
|
SHC1 events in ERBB2 signaling |
|
|
SHC1 events in ERBB4 signaling |
|
|
Sialic acid metabolism |
|
|
Signal attenuation |
|
|
Signal regulatory protein (SIRP) family interactions |
|
|
Signal transduction by L1 |
|
|
Signaling by activated point mutants of FGFR1 |
|
|
Signaling by activated point mutants of FGFR3 |
|
|
Signaling by Activin |
|
|
Signaling by BMP |
|
|
Signaling by constitutively active EGFR |
|
|
Signaling by EGFR |
|
|
Signaling by ERBB2 |
|
|
Signaling by ERBB4 |
|
|
Signaling by FGFR |
|
|
Signaling by FGFR mutants |
|
|
Signaling by FGFR1 amplification mutants |
|
|
Signaling by FGFR1 fusion mutants |
|
|
Signaling by FGFR2 amplification mutants |
|
|
Signaling by FGFR4 mutants |
|
|
Signaling by Hippo |
|
|
Signaling by Insulin receptor |
|
|
Signaling by Leptin |
|
|
Signaling by NODAL |
|
|
Signaling by PDGF |
|
|
Signaling by SCF-KIT |
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
|
|
Signalling to ERK5 |
|
|
Signalling to STAT3 |
|
|
SMAD2/3 MH2 Domain Mutants in Cancer |
|
|
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
|
|
Smooth Muscle Contraction |
|
|
Sphingolipid de novo biosynthesis |
|
|
Sphingolipid metabolism |
|
|
Spry regulation of FGF signaling |
|
|
Stabilization of p53 |
|
|
STAT6-mediated induction of chemokines |
|
|
Stimulation of the cell death response by PAK-2p34 |
|
|
Striated Muscle Contraction |
|
|
Sulfate assimilation |
|
|
Sulfur amino acid metabolism |
|
|
Synthesis and interconversion of nucleotide di- and triphosphates |
|
|
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
|
|
Synthesis of Dolichyl-phosphate |
|
|
Synthesis of IP3 and IP4 in the cytosol |
|
|
Synthesis of IPs in the nucleus |
|
|
Synthesis of PC |
|
|
Synthesis of PE |
|
|
Synthesis of PIPs at the early endosome membrane |
|
|
Synthesis of PIPs at the ER membrane |
|
|
Synthesis of PIPs at the Golgi membrane |
|
|
Synthesis of PIPs at the late endosome membrane |
|
|
Synthesis of PIPs at the plasma membrane |
|
|
Synthesis of pyrophosphates in the cytosol |
|
|
t(4;14) translocations of FGFR3 |
|
|
TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
|
|
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
|
|
TGF-beta receptor signaling activates SMADs |
|
|
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
|
|
TGFBR1 KD Mutants in Cancer |
|
|
The canonical retinoid cycle in rods (twilight vision) |
|
|
The proton buffering model |
|
|
The tricarboxylic acid cycle |
|
|
Tie2 Signaling |
|
|
TRAF mediated activation of IRF |
|
|
TRAF3-dependent IRF activation pathway |
|
|
TRAF6 mediated induction of TAK1 complex |
|
|
TRAF6 mediated induction of the anti inflammatory cytokines |
|
|
TRAF6 mediated IRF7 activation |
|
|
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
|
|
TRAF6 mediated NF-kB activation |
|
|
Trafficking and processing of endosomal TLR |
|
|
Trafficking of AMPA receptors |
|
|
Trafficking of dietary sterols |
|
|
Trafficking of GluR2-containing AMPA receptors |
|
|
Transcription of the HIV genome |
|
|
Transcriptional activation of mitochondrial biogenesis |
|
|
Transferrin endocytosis and recycling |
|
|
Translocation of GLUT4 to the plasma membrane |
|
|
Translocation of ZAP-70 to Immunological synapse |
|
|
Transport and synthesis of PAPS |
|
|
Triglyceride Biosynthesis |
|
|
Tristetraprolin (TTP) destabilizes mRNA |
|
|
TRKA activation by NGF |
|
|
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A |
|
|
Ubiquitin-dependent degradation of Cyclin D1 |
|
|
Urea cycle |
|
|
VEGFA-VEGFR2 Pathway |
|
|
VEGFR2 mediated cell proliferation |
|
|
VEGFR2 mediated vascular permeability |
|
|
Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK |
|
|
Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1 |
|
|
Vitamin B1 (thiamin) metabolism |
|
|
Vitamin B2 (riboflavin) metabolism |
|
|
Vitamins B6 activation to pyridoxal phosphate |
|
|
WNT mediated activation of DVL |
|
|
WNT5A-dependent internalization of FZD4 |
|
