| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 16th, 2008 | 23 | No |
Popular Name: Piroxicam Piroxicam
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1488516-58-0 , 36322-90-4
2-methyl-4-oxo-N-pyridin-2-yl-3,4-dihydro-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.88 | 2.04 | -14.3 | 2 | 7 | 0 | 100 | 331.353 | 2 | ↓ |
| Ref Reference (pH 7) | 1.06 | 1.35 | -39.98 | 1 | 7 | -1 | 101 | 330.345 | 1 | ↓ |
| Hi High (pH 8-9.5) | 0.88 | 3.88 | -50.96 | 1 | 7 | -1 | 102 | 330.345 | 2 | ↓ |
| Lo Low (pH 4.5-6) | 0.88 | 2.52 | -42.66 | 3 | 7 | 1 | 101 | 332.361 | 2 | ↓ |
| Lo Low (pH 4.5-6) | 1.06 | 1.81 | -21.25 | 2 | 7 | 0 | 103 | 331.353 | 1 | ↓ |
| Lo Low (pH 4.5-6) | 0.88 | 3.36 | -49.01 | 3 | 7 | 1 | 101 | 332.361 | 2 | ↓ |
| Lo Low (pH 4.5-6) | 1.06 | 0.5 | -20.08 | 2 | 7 | 0 | 103 | 331.353 | 1 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| biological_use | Antiinflammatory agent | IBScreen Bioactives |
| mechanism | Piroxicam also inhibits the migration of leukocytes into sites of inflammation and prevents the formation of thromboxane A2, an aggregating agent, by the platelets | IBScreen Bioactives |
| mechanism | Piroxicam blocks the Cox-1 enzyme, resulting into the disruption of production of prostaglandins. | IBScreen Bioactives |
| mechanism | Reversible inhibitor of cyclooxygenase, causing the peripheral inhibition of prostaglandin synthesis. | IBScreen Bioactives |
| mechanism | The prostaglandins are produced by an enzyme called Cox-1. | IBScreen Bioactives |
