UCSF

ZINC13447797

Substance Information

In ZINC since Heavy atoms Benign functionality
June 19th, 2008 30 No

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.51 10.31 -16.61 1 8 0 106 400.394 3

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
KPCG-1-E Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic Eukaryotes 1500 0.27 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
KPCG_RAT P63319 Protein Kinase C Gamma, Rat 1500 0.27 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Calmodulin induced events
Disinhibition of SNARE formation
G alpha (z) signalling events
Response to elevated platelet cytosolic Ca2+
Trafficking of GluR2-containing AMPA receptors
WNT5A-dependent internalization of FZD4

Analogs ( Draw Identity 99% 90% 80% 70% )