| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 21st, 2008 | 22 | No |
Popular Name: N-(Diaminomethylene)-2-methyl-5-(methylsulfonyl)-4-(1H-pyrrol-1-yl)benzamide N-(Diaminomethylene)-2-methyl-5-…
Find On: PubMed — Wikipedia — Google
CAS Numbers: 176644-21-6 , [176644-21-6]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.37 | 3.65 | -13.7 | 4 | 7 | 0 | 121 | 320.374 | 3 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Purity | 95% | Fluorochem |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SL9A1-1-E | Sodium/hydrogen Exchanger 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.52 | Binding ≤ 10μM |
| SL9A2-1-E | Sodium/hydrogen Exchanger 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.52 | Binding ≤ 10μM |
| SL9A3-1-E | Sodium/hydrogen Exchanger 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.52 | Binding ≤ 10μM |
| SL9A1-1-E | Sodium/hydrogen Exchanger 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.52 | Functional ≤ 10μM |
| SL9A2-1-E | Sodium/hydrogen Exchanger 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 9200 | 0.32 | Functional ≤ 10μM |
| SL9A3-1-E | Sodium/hydrogen Exchanger 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 8 | 0.52 | Functional ≤ 10μM |
| Z50587-1-O | Homo Sapiens (cluster #1 Of 9), Other | Other | 32 | 0.48 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SL9A1_RABIT | P23791 | Sodium/hydrogen Exchanger 1, Rabit | 8 | 0.52 | Binding ≤ 1μM |
| SL9A1_HUMAN | P19634 | Sodium/hydrogen Exchanger 1, Human | 400 | 0.41 | Binding ≤ 1μM |
| SL9A2_RABIT | P50482 | Sodium/hydrogen Exchanger 2, Rabit | 8 | 0.52 | Binding ≤ 1μM |
| SL9A3_RABIT | P26432 | Sodium/hydrogen Exchanger 3, Rabit | 8 | 0.52 | Binding ≤ 1μM |
| SL9A1_RABIT | P23791 | Sodium/hydrogen Exchanger 1, Rabit | 8 | 0.52 | Binding ≤ 10μM |
| SL9A1_HUMAN | P19634 | Sodium/hydrogen Exchanger 1, Human | 400 | 0.41 | Binding ≤ 10μM |
| SL9A2_RABIT | P50482 | Sodium/hydrogen Exchanger 2, Rabit | 8 | 0.52 | Binding ≤ 10μM |
| SL9A3_RABIT | P26432 | Sodium/hydrogen Exchanger 3, Rabit | 8 | 0.52 | Binding ≤ 10μM |
| Z50587 | Z50587 | Homo Sapiens | 32 | 0.48 | Functional ≤ 10μM |
| SL9A1_RABIT | P23791 | Sodium/hydrogen Exchanger 1, Rabit | 8 | 0.52 | Functional ≤ 10μM |
| SL9A1_HUMAN | P19634 | Sodium/hydrogen Exchanger 1, Human | 140 | 0.44 | Functional ≤ 10μM |
| SL9A2_HUMAN | Q9UBY0 | Sodium/hydrogen Exchanger 2, Human | 9200 | 0.32 | Functional ≤ 10μM |
| SL9A2_RABIT | P50482 | Sodium/hydrogen Exchanger 2, Rabit | 8 | 0.52 | Functional ≤ 10μM |
| SL9A3_RABIT | P26432 | Sodium/hydrogen Exchanger 3, Rabit | 8 | 0.52 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Hyaluronan uptake and degradation | |
| Sodium/Proton exchangers |
