| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 26th, 2008 | 33 | No |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.60 | 10.25 | -66.99 | 4 | 6 | 1 | 87 | 439.539 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA-1-E | Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic | Eukaryotes | 47 | 0.31 | Binding ≤ 10μM |
| KPCB-1-E | Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 47 | 0.31 | Binding ≤ 10μM |
| KPCG-1-E | Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic | Eukaryotes | 47 | 0.31 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KPCA_RAT | P05696 | Protein Kinase C Alpha, Rat | 47 | 0.31 | Binding ≤ 1μM |
| KPCB_RAT | P68403 | Protein Kinase C Beta, Rat | 47 | 0.31 | Binding ≤ 1μM |
| KPCG_RAT | P63319 | Protein Kinase C Gamma, Rat | 47 | 0.31 | Binding ≤ 1μM |
| KPCA_RAT | P05696 | Protein Kinase C Alpha, Rat | 47 | 0.31 | Binding ≤ 10μM |
| KPCB_RAT | P68403 | Protein Kinase C Beta, Rat | 47 | 0.31 | Binding ≤ 10μM |
| KPCG_RAT | P63319 | Protein Kinase C Gamma, Rat | 47 | 0.31 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of NF-kappaB in B cells | |
| Calmodulin induced events | |
| Depolymerisation of the Nuclear Lamina | |
| Disinhibition of SNARE formation | |
| G alpha (z) signalling events | |
| Response to elevated platelet cytosolic Ca2+ | |
| Trafficking of GluR2-containing AMPA receptors | |
| VEGFR2 mediated cell proliferation | |
| WNT5A-dependent internalization of FZD4 |
