| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 6th, 2004 | 23 | Yes |
Popular Name: Mequitazine Mequitazine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 147780-50-5 , 29216-28-2
10-(1-Aza-bicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
10-(1-azabicyclo(2.2.2)oct-8-ylmethyl)phenothiazine
10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
10-(1-azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine; 29216-28-2; nsc303612
10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine
10-(3-Quinuclidinylmethyl)phenothiazine
10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)-
10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)- (9CI)
10H-Phenothiazine, 10-(1-azabicyclo[2.2.2]oct-3-ylmethyl)-
29216-28-2; D01324; Kitazemin (TN); Mequitazine (JP16/INN)
3-Methylquinuclidinyl-10-phenothiazine
Italfarmaco brand of mequitazine
LM 209; Virginan; Mequitazine; 10-(3-Quinuclidinylmethyl)phenothiazine
Mequitazina [INN-Spanish];Mequitazina [Spanish];Mequitazinum [INN-Latin]
mequitazine tartrate, (R-(R*,R*))-isomer
Phenothiazine, 10-(3-quinuclidinylmethyl)-
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.11 | 0.03 | -34.85 | 1 | 2 | 1 | 9 | 323.485 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| mechanism | . | ZereneX Building Blocks |
| ALOGPS_SOLUBILITY | 4.01e-03 g/l | DrugBank-approved |
| biological_use | Antiallergic agent | IBScreen Bioactives |
| mechanism | Mequitazine binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. | IBScreen Bioactives |
| mechanism | This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine | IBScreen Bioactives |
