| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 9th, 2004 | 21 | No |
Popular Name: 6-[(5E)-4-keto-5-(2-thenylidene)-2-thioxo-thiazolidin-3-yl]hexanoate 6-[(5E)-4-keto-5-(2-thenylidene)…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.59 | -1.55 | -54.17 | 0 | 4 | -1 | 62 | 340.471 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FFAR1-1-E | Free Fatty Acid Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6600 | 0.35 | Binding ≤ 10μM |
| FFAR1-2-E | Free Fatty Acid Receptor 1 (cluster #2 Of 2), Eukaryotic | Eukaryotes | 7600 | 0.34 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FFAR1_HUMAN | O14842 | Free Fatty Acid Receptor 1, Human | 6600 | 0.35 | Binding ≤ 10μM |
| FFAR1_HUMAN | O14842 | Free Fatty Acid Receptor 1, Human | 7600 | 0.34 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | |
| Free fatty acid receptors | |
| G alpha (q) signalling events | |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp |
