| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 9th, 2004 | 22 | No |
Popular Name: 2-[(2-hydroxyethyl)amino]-5-nitro-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione 2-[(2-hydroxyethyl)amino]-5-nitr…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.10 | -3.43 | -17.58 | 2 | 8 | 0 | 117 | 301.258 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NTRK1-1-E | Nerve Growth Factor Receptor Trk-A (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5880 | 0.33 | Binding ≤ 10μM |
| TNR16-1-E | Low Affinity Neurotrophin Receptor P75NTR (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3720 | 0.35 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TNR16_HUMAN | P08138 | Low Affinity Neurotrophin Receptor P75NTR, Human | 3720 | 0.35 | Binding ≤ 10μM |
| NTRK1_HUMAN | P04629 | Nerve Growth Factor Receptor Trk-A, Human | 3720 | 0.35 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| ARMS-mediated activation | |
| Axonal growth inhibition (RHOA activation) | |
| Axonal growth stimulation | |
| Ceramide signalling | |
| Frs2-mediated activation | |
| NADE modulates death signalling | |
| NF-kB is activated and signals survival | |
| NFG and proNGF binds to p75NTR | |
| NGF-independant TRKA activation | |
| NRAGE signals death through JNK | |
| NRIF signals cell death from the nucleus | |
| p75NTR negatively regulates cell cycle via SC1 | |
| p75NTR recruits signalling complexes | |
| PI3K/AKT activation | |
| PLC-gamma1 signalling | |
| Regulated proteolysis of p75NTR | |
| Retrograde neurotrophin signalling | |
| Signalling to p38 via RIT and RIN | |
| Signalling to RAS | |
| Signalling to STAT3 | |
| TRKA activation by NGF |
No pre-computed analogs available. Try a structural similarity search.