| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 9th, 2004 | 37 | Yes |
Popular Name: 3-[1-(4-chlorobenzyl)-3-methyl-5-(2-quinolylmethoxy)indol-2-yl]-2,2-dimethyl-propionate 3-[1-(4-chlorobenzyl)-3-methyl-5…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 7.40 | 1.62 | -51.66 | 0 | 5 | -1 | 67 | 512.029 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AL5AP-1-E | 5-lipoxygenase Activating Protein (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3 | 0.32 | Binding ≤ 10μM |
| Z50587-1-O | Homo Sapiens (cluster #1 Of 9), Other | Other | 3 | 0.32 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AL5AP_HUMAN | P20292 | 5-lipoxygenase Activating Protein, Human | 2.8 | 0.32 | Binding ≤ 1μM |
| AL5AP_HUMAN | P20292 | 5-lipoxygenase Activating Protein, Human | 2.8 | 0.32 | Binding ≤ 10μM |
| Z50587 | Z50587 | Homo Sapiens | 3 | 0.32 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Synthesis of 5-eicosatetraenoic acids | |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | |
| Synthesis of Lipoxins (LX) |
