In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
October 9th, 2004 | 34 | Yes |
Popular Name: CV-11194 CV-11194
None
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 5.51 | 1.68 | -126.77 | 0 | 8 | -2 | 110 | 450.502 | 8 | ↓ |
Mid Mid (pH 6-8) | 5.51 | 1.84 | -108.98 | 1 | 8 | -1 | 107 | 451.51 | 8 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
AGTR1-1-E | Type-1 Angiotensin II Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 550 | 0.26 | Binding ≤ 10μM |
AGTR2-1-E | Angiotensin II Type 2 (AT-2) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 550 | 0.26 | Binding ≤ 10μM |
AGTR1-1-E | Angiotensin II Type 1a (AT-1a) Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 0 | 0.00 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
AGTR1_BOVIN | P25104 | Angiotensin II Type 1a (AT-1a) Receptor, Bovin | 550 | 0.26 | Binding ≤ 1μM |
AGTR2_HUMAN | P50052 | Angiotensin II Type 2 (AT-2) Receptor, Human | 550 | 0.26 | Binding ≤ 1μM |
AGTR1_BOVIN | P25104 | Angiotensin II Type 1a (AT-1a) Receptor, Bovin | 550 | 0.26 | Binding ≤ 10μM |
AGTR2_HUMAN | P50052 | Angiotensin II Type 2 (AT-2) Receptor, Human | 550 | 0.26 | Binding ≤ 10μM |
AGTR1_RABIT | P34976 | Angiotensin II Type 1a (AT-1a) Receptor, Rabit | 0.1 | 0.41 | Functional ≤ 10μM |
Description | Species |
---|---|
G alpha (i) signalling events | |
G alpha (q) signalling events | |
Peptide ligand-binding receptors |