| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 5th, 2009 | 25 | No |
Popular Name: (2E,6E)-2,6-bis[(3-bromo-4-hydroxy-phenyl)methylene]cyclohexanone (2E,6E)-2,6-bis[(3-bromo-4-hydro…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.00 | 7.59 | -10.02 | 2 | 3 | 0 | 58 | 464.153 | 2 | ↓ |
| Hi High (pH 8-9.5) | 6.00 | 8.46 | -41.76 | 1 | 3 | -1 | 60 | 463.145 | 2 | ↓ |
| Hi High (pH 8-9.5) | 6.00 | 9.09 | -81.23 | 0 | 3 | -2 | 63 | 462.137 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| EP300-1-E | Histone Acetyltransferase P300 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5000 | 0.30 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| EP300_HUMAN | Q09472 | Histone Acetyltransferase P300, Human | 5000 | 0.30 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Attenuation phase | |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | |
| Circadian Clock | |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |
| Factors involved in megakaryocyte development and platelet production | |
| formation of the beta-catenin:TCF transactivating complex | |
| HATs acetylate histones | |
| LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production | |
| NOTCH1 Intracellular Domain Regulates Transcription | |
| NOTCH2 intracellular domain regulates transcription | |
| Polo-like kinase mediated events | |
| PPARA activates gene expression | |
| Pre-NOTCH Transcription and Translation | |
| Regulation of gene expression by Hypoxia-inducible Factor | |
| REV-ERBA represses gene expression | |
| RORA activates circadian gene expression | |
| TRAF3-dependent IRF activation pathway | |
| TRAF6 mediated IRF7 activation | |
| Transcriptional regulation of white adipocyte differentiation |
