Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	3.24	9.62	-58.92	3	5	1	60	448.562	5	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	3.24	7.33	-15.56	2	5	0	59	447.554	5	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
5HT1A-1-E	Serotonin 1a (5-HT1a) Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	307	0.28	Binding ≤ 10μM
5HT1D-1-E	Serotonin 1d (5-HT1d) Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	14	0.33	Binding ≤ 10μM
SC6A4-1-E	Serotonin Transporter (cluster #1 Of 4), Eukaryotic	Eukaryotes	2	0.37	Binding ≤ 10μM
Z104304-1-O	Adrenergic Receptor Alpha-1 (cluster #1 Of 3), Other	Other	91	0.30	Binding ≤ 10μM
DRD2-4-E	Dopamine D2 Receptor (cluster #4 Of 24), Eukaryotic	Eukaryotes	1170	0.25	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
Z104304	Z104304	Adrenergic Receptor Alpha-1	91	0.30	Binding ≤ 1μM
5HT1A_HUMAN	P08908	Serotonin 1a (5-HT1a) Receptor, Human	307	0.28	Binding ≤ 1μM
5HT1D_HUMAN	P28221	Serotonin 1d (5-HT1d) Receptor, Human	14	0.33	Binding ≤ 1μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	2.1	0.37	Binding ≤ 1μM
Z104304	Z104304	Adrenergic Receptor Alpha-1	91	0.30	Binding ≤ 10μM
DRD2_RAT	P61169	Dopamine D2 Receptor, Rat	1170	0.25	Binding ≤ 10μM
5HT1A_HUMAN	P08908	Serotonin 1a (5-HT1a) Receptor, Human	307	0.28	Binding ≤ 10μM
5HT1D_HUMAN	P28221	Serotonin 1d (5-HT1d) Receptor, Human	14	0.33	Binding ≤ 10μM
SC6A4_HUMAN	P31645	Serotonin Transporter, Human	2.1	0.37	Binding ≤ 10μM

Description	Species
Dopamine receptors	Rattus norvegicus (DRD2_RAT)
G alpha (i) signalling events	Homo sapiens (5HT1A_HUMAN) Rattus norvegicus (DRD2_RAT)
Serotonin receptors	Homo sapiens (5HT1A_HUMAN)