| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 8th, 2009 | 19 | No |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.51 | 3.57 | -12.78 | 3 | 3 | 0 | 61 | 258.317 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IGF1R-1-E | Insulin-like Growth Factor 1 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1000 | 0.44 | Binding ≤ 10μM |
| LOX15-3-E | Arachidonate 15-lipoxygenase (cluster #3 Of 5), Eukaryotic | Eukaryotes | 9400 | 0.37 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IGF1R_HUMAN | P08069 | Insulin-like Growth Factor I Receptor, Human | 1000 | 0.44 | Binding ≤ 1μM |
| LOX15_HUMAN | P16050 | Arachidonate 15-lipoxygenase, Human | 9400 | 0.37 | Binding ≤ 10μM |
| IGF1R_HUMAN | P08069 | Insulin-like Growth Factor I Receptor, Human | 1000 | 0.44 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| IRS-related events triggered by IGF1R | |
| SHC-related events triggered by IGF1R | |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | |
| Synthesis of 12-eicosatetraenoic acid derivatives | |
| Synthesis of 15-eicosatetraenoic acid derivatives | |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) |
