| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 9th, 2009 | 27 | Yes |
Popular Name: N-(4-butylphenyl)-2-(4-pyridylmethylamino)pyridine-3-carboxamide N-(4-butylphenyl)-2-(4-pyridylme…
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.71 | 9.93 | -12.01 | 2 | 5 | 0 | 67 | 360.461 | 8 | ↓ |
| Lo Low (pH 4.5-6) | 3.71 | 10.29 | -44.66 | 3 | 5 | 1 | 68 | 361.469 | 8 | ↓ |
| Lo Low (pH 4.5-6) | 3.71 | 10.73 | -88.95 | 4 | 5 | 2 | 69 | 362.477 | 8 | ↓ |
| Lo Low (pH 4.5-6) | 3.71 | 10.37 | -38.35 | 3 | 5 | 1 | 68 | 361.469 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| VGFR2-1-E | Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 19 | 0.40 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 19 | 0.40 | Binding ≤ 1μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 19 | 0.40 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| EPHA-mediated growth cone collapse | |
| Integrin cell surface interactions | |
| Neurophilin interactions with VEGF and VEGFR | |
| VEGF binds to VEGFR leading to receptor dimerization | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation |
