| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| August 1st, 2009 | 22 | No |
Popular Name: 3-[5-[(Z)-(2,4-dioxothiazolidin-5-ylidene)methyl]-2-furyl]benzoic 3-[5-[(Z)-(2,4-dioxothiazolidin-…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.55 | 5.84 | -62.92 | 1 | 6 | -1 | 103 | 314.298 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PK3CG-2-E | PI3-kinase P110-gamma Subunit (cluster #2 Of 3), Eukaryotic | Eukaryotes | 4300 | 0.34 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PK3CG_HUMAN | P48736 | PI3-kinase P110-gamma Subunit, Human | 4300 | 0.34 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| G beta:gamma signalling through PI3Kgamma | |
| GPVI-mediated activation cascade | |
| Synthesis of PIPs at the plasma membrane |
