| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| August 31st, 2009 | 32 | Yes |
Popular Name: KeratinocyteDifferentiationInducer KeratinocyteDifferentiationInducer
Find On: PubMed — Wikipedia — Google
CAS Number: 863598-09-8
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.91 | 14.16 | -18.6 | 1 | 8 | 0 | 94 | 429.48 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FAK1-1-E | Focal Adhesion Kinase 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 93 | 0.31 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FAK1_HUMAN | Q05397 | Focal Adhesion Kinase 1, Human | 93 | 0.31 | Binding ≤ 1μM |
| FAK1_HUMAN | Q05397 | Focal Adhesion Kinase 1, Human | 93 | 0.31 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Apoptotic cleavage of cellular proteins | |
| DCC mediated attractive signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |
| Integrin alphaIIb beta3 signaling | |
| NCAM signaling for neurite out-growth | |
| Netrin mediated repulsion signals | |
| p130Cas linkage to MAPK signaling for integrins | |
| Regulation of actin dynamics for phagocytic cup formation | |
| Signal regulatory protein (SIRP) family interactions | |
| VEGFA-VEGFR2 Pathway |
No pre-computed analogs available. Try a structural similarity search.