| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 29th, 2009 | 21 | No |
Popular Name: (5Z)-5-[[5-(2,4-difluorophenyl)-2-furyl]methylene]thiazolidine-2,4-dione (5Z)-5-[[5-(2,4-difluorophenyl)-…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.91 | 5.43 | -8.82 | 1 | 4 | 0 | 63 | 307.277 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PK3CG-2-E | PI3-kinase P110-gamma Subunit (cluster #2 Of 3), Eukaryotic | Eukaryotes | 3800 | 0.36 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PK3CG_HUMAN | P48736 | PI3-kinase P110-gamma Subunit, Human | 3800 | 0.36 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| G beta:gamma signalling through PI3Kgamma | |
| GPVI-mediated activation cascade | |
| Synthesis of PIPs at the plasma membrane |
