In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
October 1st, 2009 | 19 | Yes |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 1.99 | 5.49 | -9.99 | 1 | 5 | 0 | 58 | 257.293 | 2 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
PK3CA-2-E | PI3-kinase P110-alpha Subunit (cluster #2 Of 2), Eukaryotic | Eukaryotes | 260 | 0.49 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
PK3CA_HUMAN | P42336 | PI3-kinase P110-alpha Subunit, Human | 260 | 0.49 | Binding ≤ 1μM |
PK3CA_HUMAN | P42336 | PI3-kinase P110-alpha Subunit, Human | 260 | 0.49 | Binding ≤ 10μM |
Description | Species |
---|---|
CD28 dependent PI3K/Akt signaling | |
Constitutive PI3K/AKT Signaling in Cancer | |
Costimulation by the CD28 family | |
DAP12 signaling | |
Downstream signal transduction | |
Downstream TCR signaling | |
G alpha (12/13) signalling events | |
G alpha (q) signalling events | |
GAB1 signalosome | |
GPVI-mediated activation cascade | |
Interleukin receptor SHC signaling | |
Interleukin-3, 5 and GM-CSF signaling | |
Nephrin interactions | |
PI-3K cascade | |
PI3K Cascade | |
PI3K events in ERBB2 signaling | |
PI3K events in ERBB4 signaling | |
PI3K/AKT activation | |
PIP3 activates AKT signaling | |
Regulation of signaling by CBL | |
Role of LAT2/NTAL/LAB on calcium mobilization | |
Role of phospholipids in phagocytosis | |
Signaling by constitutively active EGFR | |
Signaling by FGFR mutants | |
Signaling by FGFR1 fusion mutants | |
Signaling by SCF-KIT | |
Synthesis of PIPs at the plasma membrane | |
Tie2 Signaling | |
VEGFA-VEGFR2 Pathway |