| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 26th, 2009 | 35 | Yes |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.96 | 17.91 | -136.94 | 0 | 5 | -2 | 97 | 488.709 | 11 | ↓ |
| Mid Mid (pH 6-8) | 6.96 | 15.94 | -48.53 | 1 | 5 | -1 | 94 | 489.717 | 11 | ↓ |
| Mid Mid (pH 6-8) | 6.96 | 15.88 | -60.93 | 1 | 5 | -1 | 94 | 489.717 | 11 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FNTA-3-E | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #3 Of 3), Eukaryotic | Eukaryotes | 3000 | 0.22 | Binding ≤ 10μM |
| FNTB-3-E | Protein Farnesyltransferase Beta Subunit (cluster #3 Of 3), Eukaryotic | Eukaryotes | 3000 | 0.22 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 3000 | 0.22 | Binding ≤ 10μM |
| FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 3000 | 0.22 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Apoptotic cleavage of cellular proteins | |
| Inactivation, recovery and regulation of the phototransduction cascade |
![1,2,3,3a,4,5,5a,6,8,9,9a,9b-dodecahydrocyclopenta[a]naphthalen-7-one](http://zinc12.docking.org/img/rings/88224.gif)
