| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 21st, 2009 | 19 | No |
Popular Name: DNC011184 DNC011184
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.89 | 0.87 | -10.83 | 4 | 5 | 0 | 81 | 255.277 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IGF1R-1-E | Insulin-like Growth Factor 1 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 1500 | 0.43 | Binding ≤ 10μM |
| INSR-1-E | Insulin Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2250 | 0.42 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| INSR_HUMAN | P06213 | Insulin Receptor, Human | 2250 | 0.42 | Binding ≤ 10μM |
| IGF1R_HUMAN | P08069 | Insulin-like Growth Factor I Receptor, Human | 1500 | 0.43 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Insulin receptor recycling | |
| IRS activation | |
| IRS-related events triggered by IGF1R | |
| SHC activation | |
| SHC-related events triggered by IGF1R | |
| Signal attenuation | |
| Signaling by Insulin receptor | |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
