In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
September 26th, 2005 | 35 | No |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.43 | -4.78 | -19.77 | 2 | 8 | 0 | 94 | 467.481 | 2 | ↓ |
Note Type | Comments | Provided By |
---|---|---|
S phrase | S24/25: Avoid contact with skin and eyes. | Acros Organics |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
KCC1A-1-E | CaM Kinase I Alpha (cluster #1 Of 2), Eukaryotic | Eukaryotes | 270 | 0.26 | Binding ≤ 10μM |
KCC2A-1-E | CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic | Eukaryotes | 270 | 0.26 | Binding ≤ 10μM |
KCC2B-1-E | CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 270 | 0.26 | Binding ≤ 10μM |
KCC2D-1-E | CaM Kinase II Delta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 270 | 0.26 | Binding ≤ 10μM |
KCC2G-1-E | CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic | Eukaryotes | 270 | 0.26 | Binding ≤ 10μM |
KCC4-1-E | CaM Kinase IV (cluster #1 Of 1), Eukaryotic | Eukaryotes | 270 | 0.26 | Binding ≤ 10μM |
KPB1-1-E | Phosphorylase Kinase Alpha M Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.35 | Binding ≤ 10μM |
KPB2-1-E | Phosphorylase Kinase Alpha L Subunit (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2 | 0.35 | Binding ≤ 10μM |
KPBB-1-E | Phosphorylase Kinase Beta Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2 | 0.35 | Binding ≤ 10μM |
KPCA-1-E | Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCB-1-E | Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCD-1-E | Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCD1-3-E | Protein Kinase C Mu (cluster #3 Of 3), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCD3-3-E | Protein Kinase C Nu (cluster #3 Of 3), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCE-1-E | Protein Kinase C Epsilon (cluster #1 Of 5), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCG-1-E | Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic | Eukaryotes | 470 | 0.25 | Binding ≤ 10μM |
KPCI-2-E | Protein Kinase C Iota (cluster #2 Of 3), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCL-2-E | Protein Kinase C Eta (cluster #2 Of 4), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCT-1-E | Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
KPCZ-1-E | Protein Kinase C Zeta (cluster #1 Of 5), Eukaryotic | Eukaryotes | 60 | 0.29 | Binding ≤ 10μM |
PHKG1-1-E | Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2 | 0.35 | Binding ≤ 10μM |
PHKG2-1-E | Phosphorylase Kinase Gamma Subunit 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2 | 0.35 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
KCC1A_HUMAN | Q14012 | CaM Kinase I Alpha, Human | 270 | 0.26 | Binding ≤ 1μM |
KCC2A_HUMAN | Q9UQM7 | CaM Kinase II Alpha, Human | 270 | 0.26 | Binding ≤ 1μM |
KCC2B_HUMAN | Q13554 | CaM Kinase II Beta, Human | 270 | 0.26 | Binding ≤ 1μM |
KCC2D_HUMAN | Q13557 | CaM Kinase II Delta, Human | 270 | 0.26 | Binding ≤ 1μM |
KCC2G_HUMAN | Q13555 | CaM Kinase II Gamma, Human | 270 | 0.26 | Binding ≤ 1μM |
KCC4_HUMAN | Q16566 | CaM Kinase IV, Human | 270 | 0.26 | Binding ≤ 1μM |
KPB2_HUMAN | P46019 | Phosphorylase Kinase Alpha L Subunit, Human | 1.7 | 0.35 | Binding ≤ 1μM |
KPB1_HUMAN | P46020 | Phosphorylase Kinase Alpha M Subunit, Human | 1.7 | 0.35 | Binding ≤ 1μM |
KPBB_HUMAN | Q93100 | Phosphorylase Kinase Beta Subunit, Human | 1.7 | 0.35 | Binding ≤ 1μM |
PHKG1_HUMAN | Q16816 | Phosphorylase Kinase Gamma Subunit 1, Human | 1.7 | 0.35 | Binding ≤ 1μM |
PHKG2_HUMAN | P15735 | Phosphorylase Kinase Gamma Subunit 2, Human | 1.7 | 0.35 | Binding ≤ 1μM |
KPCA_HUMAN | P17252 | Protein Kinase C Alpha, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCB_HUMAN | P05771 | Protein Kinase C Beta, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCD_HUMAN | Q05655 | Protein Kinase C Delta, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCE_HUMAN | Q02156 | Protein Kinase C Epsilon, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCL_HUMAN | P24723 | Protein Kinase C Eta, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCG_HUMAN | P05129 | Protein Kinase C Gamma, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCG_RAT | P63319 | Protein Kinase C Gamma, Rat | 470 | 0.25 | Binding ≤ 1μM |
KPCI_HUMAN | P41743 | Protein Kinase C Iota, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCD1_HUMAN | Q15139 | Protein Kinase C Mu, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCD3_HUMAN | O94806 | Protein Kinase C Nu, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCT_HUMAN | Q04759 | Protein Kinase C Theta, Human | 60 | 0.29 | Binding ≤ 1μM |
KPCZ_HUMAN | Q05513 | Protein Kinase C Zeta, Human | 60 | 0.29 | Binding ≤ 1μM |
KCC1A_HUMAN | Q14012 | CaM Kinase I Alpha, Human | 270 | 0.26 | Binding ≤ 10μM |
KCC2A_HUMAN | Q9UQM7 | CaM Kinase II Alpha, Human | 270 | 0.26 | Binding ≤ 10μM |
KCC2B_HUMAN | Q13554 | CaM Kinase II Beta, Human | 270 | 0.26 | Binding ≤ 10μM |
KCC2D_HUMAN | Q13557 | CaM Kinase II Delta, Human | 270 | 0.26 | Binding ≤ 10μM |
KCC2G_HUMAN | Q13555 | CaM Kinase II Gamma, Human | 270 | 0.26 | Binding ≤ 10μM |
KCC4_HUMAN | Q16566 | CaM Kinase IV, Human | 270 | 0.26 | Binding ≤ 10μM |
KPB2_HUMAN | P46019 | Phosphorylase Kinase Alpha L Subunit, Human | 1.7 | 0.35 | Binding ≤ 10μM |
KPB1_HUMAN | P46020 | Phosphorylase Kinase Alpha M Subunit, Human | 1.7 | 0.35 | Binding ≤ 10μM |
KPBB_HUMAN | Q93100 | Phosphorylase Kinase Beta Subunit, Human | 1.7 | 0.35 | Binding ≤ 10μM |
PHKG1_HUMAN | Q16816 | Phosphorylase Kinase Gamma Subunit 1, Human | 1.7 | 0.35 | Binding ≤ 10μM |
PHKG2_HUMAN | P15735 | Phosphorylase Kinase Gamma Subunit 2, Human | 1.7 | 0.35 | Binding ≤ 10μM |
KPCA_HUMAN | P17252 | Protein Kinase C Alpha, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCB_HUMAN | P05771 | Protein Kinase C Beta, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCD_HUMAN | Q05655 | Protein Kinase C Delta, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCE_HUMAN | Q02156 | Protein Kinase C Epsilon, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCL_HUMAN | P24723 | Protein Kinase C Eta, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCG_HUMAN | P05129 | Protein Kinase C Gamma, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCG_RAT | P63319 | Protein Kinase C Gamma, Rat | 470 | 0.25 | Binding ≤ 10μM |
KPCI_HUMAN | P41743 | Protein Kinase C Iota, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCD1_HUMAN | Q15139 | Protein Kinase C Mu, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCD3_HUMAN | O94806 | Protein Kinase C Nu, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCT_HUMAN | Q04759 | Protein Kinase C Theta, Human | 60 | 0.29 | Binding ≤ 10μM |
KPCZ_HUMAN | Q05513 | Protein Kinase C Zeta, Human | 60 | 0.29 | Binding ≤ 10μM |
Description | Species |
---|---|
Acetylcholine regulates insulin secretion | |
Activation of CaMK IV | |
Activation of NF-kappaB in B cells | |
Apoptotic cleavage of cellular proteins | |
Ca2+ pathway | |
Calmodulin induced events | |
CaMK IV-mediated phosphorylation of CREB | |
CREB phosphorylation through the activation of CaMKII | |
CREB phosphorylation through the activation of CaMKK | |
CREB phosphorylation through the activation of Ras | |
DAG and IP3 signaling | |
Depolymerisation of the Nuclear Lamina | |
Disinhibition of SNARE formation | |
Downstream TCR signaling | |
Effects of PIP2 hydrolysis | |
EGFR Transactivation by Gastrin | |
FCERI mediated NF-kB activation | |
G alpha (z) signalling events | |
Glycogen breakdown (glycogenolysis) | |
GPVI-mediated activation cascade | |
HSF1-dependent transactivation | |
HuR stabilizes mRNA | |
Inactivation, recovery and regulation of the phototransduction cascade | |
Interferon gamma signaling | |
Netrin-1 signaling | |
p75NTR recruits signalling complexes | |
Ras activation uopn Ca2+ infux through NMDA receptor | |
Regulation of KIT signaling | |
Response to elevated platelet cytosolic Ca2+ | |
Role of phospholipids in phagocytosis | |
Signaling by SCF-KIT | |
Sphingolipid de novo biosynthesis | |
Syndecan interactions | |
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | |
Tight junction interactions | |
Trafficking of AMPA receptors | |
Trafficking of GluR2-containing AMPA receptors | |
Transcriptional activation of mitochondrial biogenesis | |
Unblocking of NMDA receptor, glutamate binding and activation | |
VEGFR2 mediated cell proliferation | |
WNT5A-dependent internalization of FZD4 |