| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 26th, 2005 | 8 | No |
Popular Name: 3-Amino-1-hydroxypyrrolidin-2-one 3-Amino-1-hydroxypyrrolidin-2-one
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1003-51-6 , 123931-04-4 , [1003-51-6]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -1.66 | -2.73 | -51.23 | 4 | 4 | 1 | 68 | 117.128 | 0 | ↓ |
| Hi High (pH 8-9.5) | -1.66 | -3.03 | -8.73 | 3 | 4 | 0 | 67 | 116.12 | 0 | ↓ |
| Hi High (pH 8-9.5) | -1.66 | -1.72 | -69.53 | 3 | 4 | 0 | 71 | 116.12 | 0 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMDE3-3-E | Glutamate [NMDA] Receptor Subunit Epsilon 3 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 2500 | 0.98 | Binding ≤ 10μM |
| Z50597-6-O | Rattus Norvegicus (cluster #6 Of 12), Other | Other | 6300 | 0.91 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NMDE3_RAT | Q00961 | Glutamate [NMDA] Receptor Subunit Epsilon 3, Rat | 2500 | 0.98 | Binding ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 2500 | 0.98 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| CREB phosphorylation through the activation of CaMKII | |
| Ras activation uopn Ca2+ infux through NMDA receptor | |
| Unblocking of NMDA receptor, glutamate binding and activation |
No pre-computed analogs available. Try a structural similarity search.