UCSF

ZINC03812168

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
September 27th, 2005 35 No

Popular Name: LY-333531 LY-333531

Find On: PubMed — Wikipedia — Google

CAS Numbers: 169939-93-9 , 192050-59-2 , [169939-93-9]

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.73 0.01 -62.92 2 7 1 73 469.565 2 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
AAK1-1-E Adaptor-associated Kinase (cluster #1 Of 2), Eukaryotic Eukaryotes 960 0.24 Binding ≤ 10μM
AKT3-2-E Serine/threonine-protein Kinase AKT3 (cluster #2 Of 2), Eukaryotic Eukaryotes 1400 0.23 Binding ≤ 10μM
AURKC-1-E Serine/threonine-protein Kinase Aurora-C (cluster #1 Of 2), Eukaryotic Eukaryotes 3000 0.22 Binding ≤ 10μM
BMP2K-1-E BMP-2-inducible Protein Kinase (cluster #1 Of 2), Eukaryotic Eukaryotes 430 0.25 Binding ≤ 10μM
CDK16-1-E Serine/threonine-protein Kinase PCTAIRE-1 (cluster #1 Of 1), Eukaryotic Eukaryotes 8000 0.20 Binding ≤ 10μM
CHK1-1-E Serine/threonine-protein Kinase Chk1 (cluster #1 Of 2), Eukaryotic Eukaryotes 540 0.25 Binding ≤ 10μM
CLK1-1-E Dual Specificty Protein Kinase CLK1 (cluster #1 Of 2), Eukaryotic Eukaryotes 910 0.24 Binding ≤ 10μM
CLK2-1-E Dual Specificity Protein Kinase CLK2 (cluster #1 Of 2), Eukaryotic Eukaryotes 420 0.26 Binding ≤ 10μM
CLK4-1-E Dual Specificity Protein Kinase CLK4 (cluster #1 Of 2), Eukaryotic Eukaryotes 8300 0.20 Binding ≤ 10μM
CSK21-1-E Casein Kinase II Alpha (cluster #1 Of 3), Eukaryotic Eukaryotes 3600 0.22 Binding ≤ 10μM
CSK22-1-E Casein Kinase II Alpha (prime) (cluster #1 Of 2), Eukaryotic Eukaryotes 3400 0.22 Binding ≤ 10μM
CTRO-1-E Citron Rho-interacting Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 1400 0.23 Binding ≤ 10μM
DAPK1-1-E Death-associated Protein Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 970 0.24 Binding ≤ 10μM
DAPK2-1-E Death-associated Protein Kinase 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 2600 0.22 Binding ≤ 10μM
DAPK3-1-E Death-associated Protein Kinase 3 (cluster #1 Of 2), Eukaryotic Eukaryotes 1300 0.24 Binding ≤ 10μM
DMPK-1-E Myotonin-protein Kinase (cluster #1 Of 1), Eukaryotic Eukaryotes 280 0.26 Binding ≤ 10μM
DYR1B-1-E Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B (cluster #1 Of 1), Eukaryotic Eukaryotes 5400 0.21 Binding ≤ 10μM
FGFR1-1-E Fibroblast Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 5100 0.21 Binding ≤ 10μM
FLT3-1-E Tyrosine-protein Kinase Receptor FLT3 (cluster #1 Of 1), Eukaryotic Eukaryotes 980 0.24 Binding ≤ 10μM
GAK-1-E Serine/threonine-protein Kinase GAK (cluster #1 Of 2), Eukaryotic Eukaryotes 1300 0.24 Binding ≤ 10μM
GSK3B-1-E Glycogen Synthase Kinase-3 Beta (cluster #1 Of 7), Eukaryotic Eukaryotes 2600 0.22 Binding ≤ 10μM
HCK-1-E Tyrosine-protein Kinase HCK (cluster #1 Of 1), Eukaryotic Eukaryotes 2800 0.22 Binding ≤ 10μM
JAK3-1-E Tyrosine-protein Kinase JAK3 (cluster #1 Of 2), Eukaryotic Eukaryotes 420 0.26 Binding ≤ 10μM
KAPCA-1-E CAMP-dependent Protein Kinase Alpha-catalytic Subunit (cluster #1 Of 4), Eukaryotic Eukaryotes 5400 0.21 Binding ≤ 10μM
KAPCB-1-E CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit (cluster #1 Of 3), Eukaryotic Eukaryotes 3200 0.22 Binding ≤ 10μM
KCC1A-1-E CaM Kinase I Alpha (cluster #1 Of 2), Eukaryotic Eukaryotes 6200 0.21 Binding ≤ 10μM
KCC1D-1-E CaM Kinase I Delta (cluster #1 Of 2), Eukaryotic Eukaryotes 2600 0.22 Binding ≤ 10μM
KCC2A-1-E CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 9600 0.20 Binding ≤ 10μM
KCC2B-1-E CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 6200 0.21 Binding ≤ 10μM
KCC2D-1-E CaM Kinase II Delta (cluster #1 Of 1), Eukaryotic Eukaryotes 6200 0.21 Binding ≤ 10μM
KCC2G-1-E CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic Eukaryotes 7800 0.20 Binding ≤ 10μM
KCC4-1-E CaM Kinase IV (cluster #1 Of 1), Eukaryotic Eukaryotes 6200 0.21 Binding ≤ 10μM
KGP2-1-E CGMP-dependent Protein Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 3100 0.22 Binding ≤ 10μM
KIT-1-E Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic Eukaryotes 920 0.24 Binding ≤ 10μM
KKCC1-1-E CaM-kinase Kinase Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 5000 0.21 Binding ≤ 10μM
KKCC2-1-E CaM-kinase Kinase Beta (cluster #1 Of 2), Eukaryotic Eukaryotes 2400 0.22 Binding ≤ 10μM
KPCA-1-E Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic Eukaryotes 360 0.26 Binding ≤ 10μM
KPCB-1-E Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic Eukaryotes 320 0.26 Binding ≤ 10μM
KPCD-1-E Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic Eukaryotes 4 0.34 Binding ≤ 10μM
KPCD2-1-E Serine/threonine-protein Kinase D2 (cluster #1 Of 1), Eukaryotic Eukaryotes 890 0.24 Binding ≤ 10μM
KPCE-1-E Protein Kinase C Epsilon (cluster #1 Of 5), Eukaryotic Eukaryotes 600 0.25 Binding ≤ 10μM
KPCG-1-E Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic Eukaryotes 320 0.26 Binding ≤ 10μM
KPCL-2-E Protein Kinase C Eta (cluster #2 Of 4), Eukaryotic Eukaryotes 320 0.26 Binding ≤ 10μM
KPCT-1-E Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic Eukaryotes 320 0.26 Binding ≤ 10μM
KPCZ-1-E Protein Kinase C Zeta (cluster #1 Of 5), Eukaryotic Eukaryotes 320 0.26 Binding ≤ 10μM
KS6A1-1-E Ribosomal Protein S6 Kinase Alpha 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 400 0.26 Binding ≤ 10μM
KS6A2-1-E Ribosomal Protein S6 Kinase Alpha 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 280 0.26 Binding ≤ 10μM
KS6A3-1-E Ribosomal Protein S6 Kinase Alpha 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 3600 0.22 Binding ≤ 10μM
KS6A4-1-E Ribosomal Protein S6 Kinase Alpha 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 6100 0.21 Binding ≤ 10μM
KS6A5-1-E Ribosomal Protein S6 Kinase Alpha 5 (cluster #1 Of 3), Eukaryotic Eukaryotes 2000 0.23 Binding ≤ 10μM
KS6A6-1-E Ribosomal Protein S6 Kinase Alpha 6 (cluster #1 Of 1), Eukaryotic Eukaryotes 2300 0.23 Binding ≤ 10μM
LATS1-1-E Serine/threonine-protein Kinase LATS1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2600 0.22 Binding ≤ 10μM
LATS2-1-E Serine/threonine-protein Kinase LATS2 (cluster #1 Of 1), Eukaryotic Eukaryotes 640 0.25 Binding ≤ 10μM
LCK-1-E Tyrosine-protein Kinase LCK (cluster #1 Of 4), Eukaryotic Eukaryotes 1300 0.24 Binding ≤ 10μM
M3K9-1-E Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic Eukaryotes 1400 0.23 Binding ≤ 10μM
M4K1-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 2600 0.22 Binding ≤ 10μM
M4K3-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 8400 0.20 Binding ≤ 10μM
M4K5-1-E Mitogen-activated Protein Kinase Kinase Kinase Kinase 5 (cluster #1 Of 1), Eukaryotic Eukaryotes 8400 0.20 Binding ≤ 10μM
MARK2-1-E MAP/microtubule Affinity-regulating Kinase 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 2300 0.23 Binding ≤ 10μM
MK15-1-E Mitogen-activated Protein Kinase 15 (cluster #1 Of 1), Eukaryotic Eukaryotes 88 0.28 Binding ≤ 10μM
MP2K4-1-E Dual Specificity Mitogen-activated Protein Kinase Kinase 4 (cluster #1 Of 1), Eukaryotic Eukaryotes 930 0.24 Binding ≤ 10μM
MYLK-1-E Myosin Light Chain Kinase, Smooth Muscle (cluster #1 Of 1), Eukaryotic Eukaryotes 290 0.26 Binding ≤ 10μM
NUAK1-1-E NUAK Family SNF1-like Kinase 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 1800 0.23 Binding ≤ 10μM
NUAK2-1-E NUAK Family SNF1-like Kinase 2 (cluster #1 Of 1), Eukaryotic Eukaryotes 320 0.26 Binding ≤ 10μM
PDPK1-1-E 3-phosphoinositide Dependent Protein Kinase-1 (cluster #1 Of 2), Eukaryotic Eukaryotes 700 0.25 Binding ≤ 10μM
PGFRB-1-E Platelet-derived Growth Factor Receptor Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 7000 0.21 Binding ≤ 10μM
PHKG1-1-E Phosphorylase Kinase Gamma Subunit 1 (cluster #1 Of 2), Eukaryotic Eukaryotes 3700 0.22 Binding ≤ 10μM
PI42B-1-E Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 830 0.24 Binding ≤ 10μM
PI51A-1-E Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 690 0.25 Binding ≤ 10μM
PIM1-1-E Serine/threonine-protein Kinase PIM1 (cluster #1 Of 1), Eukaryotic Eukaryotes 55 0.29 Binding ≤ 10μM
PIM2-1-E Serine/threonine-protein Kinase PIM2 (cluster #1 Of 2), Eukaryotic Eukaryotes 1700 0.23 Binding ≤ 10μM
PIM3-1-E Serine/threonine-protein Kinase PIM3 (cluster #1 Of 1), Eukaryotic Eukaryotes 12 0.32 Binding ≤ 10μM
PKN1-1-E Protein Kinase N1 (cluster #1 Of 1), Eukaryotic Eukaryotes 350 0.26 Binding ≤ 10μM
PKN2-1-E Protein Kinase N2 (cluster #1 Of 1), Eukaryotic Eukaryotes 1500 0.23 Binding ≤ 10μM
PLK4-1-E Serine/threonine-protein Kinase PLK4 (cluster #1 Of 1), Eukaryotic Eukaryotes 4700 0.21 Binding ≤ 10μM
RIOK1-1-E Serine/threonine-protein Kinase RIO1 (cluster #1 Of 1), Eukaryotic Eukaryotes 810 0.24 Binding ≤ 10μM
SLK-1-E Serine/threonine-protein Kinase 2 (cluster #1 Of 2), Eukaryotic Eukaryotes 940 0.24 Binding ≤ 10μM
STK10-1-E Serine/threonine-protein Kinase 10 (cluster #1 Of 1), Eukaryotic Eukaryotes 280 0.26 Binding ≤ 10μM
STK3-1-E Serine/threonine-protein Kinase MST2 (cluster #1 Of 2), Eukaryotic Eukaryotes 90 0.28 Binding ≤ 10μM
STK33-1-E Serine/threonine-protein Kinase 33 (cluster #1 Of 1), Eukaryotic Eukaryotes 3100 0.22 Binding ≤ 10μM
STK4-1-E Serine/threonine-protein Kinase MST1 (cluster #1 Of 2), Eukaryotic Eukaryotes 220 0.27 Binding ≤ 10μM
TNIK-1-E TRAF2- And NCK-interacting Kinase (cluster #1 Of 2), Eukaryotic Eukaryotes 5800 0.21 Binding ≤ 10μM
Z100405-1-O MV4-11 (Myeloid Leukemia Cells) (cluster #1 Of 1), Other Other 1500 0.23 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
PDPK1_HUMAN O15530 3-phosphoinositide Dependent Protein Kinase-1, Human 700 0.25 Binding ≤ 1μM
AAK1_HUMAN Q2M2I8 Adaptor-associated Kinase, Human 900 0.24 Binding ≤ 1μM
BMP2K_HUMAN Q9NSY1 BMP-2-inducible Protein Kinase, Human 430 0.25 Binding ≤ 1μM
DAPK1_HUMAN P53355 Death-associated Protein Kinase 1, Human 970 0.24 Binding ≤ 1μM
MP2K4_HUMAN P45985 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 930 0.24 Binding ≤ 1μM
CLK2_HUMAN P49760 Dual Specificity Protein Kinase CLK2, Human 420 0.26 Binding ≤ 1μM
CLK1_HUMAN P49759 Dual Specificty Protein Kinase CLK1, Human 910 0.24 Binding ≤ 1μM
MK15_HUMAN Q8TD08 Mitogen-activated Protein Kinase 15, Human 88 0.28 Binding ≤ 1μM
MYLK_HUMAN Q15746 Myosin Light Chain Kinase, Smooth Muscle, Human 290 0.26 Binding ≤ 1μM
DMPK_HUMAN Q09013 Myotonin-protein Kinase, Human 280 0.26 Binding ≤ 1μM
NUAK2_HUMAN Q9H093 NUAK Family SNF1-like Kinase 2, Human 320 0.26 Binding ≤ 1μM
PI51A_HUMAN Q99755 Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha, Human 690 0.25 Binding ≤ 1μM
PI42B_HUMAN P78356 Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta, Human 830 0.24 Binding ≤ 1μM
KPCA_HUMAN P17252 Protein Kinase C Alpha, Human 360 0.26 Binding ≤ 1μM
KPCA_RAT P05696 Protein Kinase C Alpha, Rat 320 0.26 Binding ≤ 1μM
KPCB_RAT P68403 Protein Kinase C Beta, Rat 320 0.26 Binding ≤ 1μM
KPCB_HUMAN P05771 Protein Kinase C Beta, Human 4.7 0.33 Binding ≤ 1μM
KPCD_RAT P09215 Protein Kinase C Delta, Rat 320 0.26 Binding ≤ 1μM
KPCD_HUMAN Q05655 Protein Kinase C Delta, Human 250 0.26 Binding ≤ 1μM
KPCE_HUMAN Q02156 Protein Kinase C Epsilon, Human 600 0.25 Binding ≤ 1μM
KPCE_RAT P09216 Protein Kinase C Epsilon, Rat 320 0.26 Binding ≤ 1μM
KPCL_RAT Q64617 Protein Kinase C Eta, Rat 320 0.26 Binding ≤ 1μM
KPCL_HUMAN P24723 Protein Kinase C Eta, Human 52 0.29 Binding ≤ 1μM
KPCG_RAT P63319 Protein Kinase C Gamma, Rat 320 0.26 Binding ≤ 1μM
KPCG_HUMAN P05129 Protein Kinase C Gamma, Human 300 0.26 Binding ≤ 1μM
KPCT_RAT Q9WTQ0 Protein Kinase C Theta, Rat 320 0.26 Binding ≤ 1μM
KPCT_HUMAN Q04759 Protein Kinase C Theta, Human 2.5 0.34 Binding ≤ 1μM
KPCZ_RAT P09217 Protein Kinase C Zeta, Rat 320 0.26 Binding ≤ 1μM
PKN1_HUMAN Q16512 Protein Kinase N1, Human 350 0.26 Binding ≤ 1μM
KS6A1_HUMAN Q15418 Ribosomal Protein S6 Kinase Alpha 1, Human 400 0.26 Binding ≤ 1μM
KS6A2_HUMAN Q15349 Ribosomal Protein S6 Kinase Alpha 2, Human 280 0.26 Binding ≤ 1μM
STK10_HUMAN O94804 Serine/threonine-protein Kinase 10, Human 280 0.26 Binding ≤ 1μM
SLK_HUMAN Q9H2G2 Serine/threonine-protein Kinase 2, Human 400 0.26 Binding ≤ 1μM
CHK1_HUMAN O14757 Serine/threonine-protein Kinase Chk1, Human 540 0.25 Binding ≤ 1μM
KPCD2_HUMAN Q9BZL6 Serine/threonine-protein Kinase D2, Human 890 0.24 Binding ≤ 1μM
LATS2_HUMAN Q9NRM7 Serine/threonine-protein Kinase LATS2, Human 640 0.25 Binding ≤ 1μM
STK4_HUMAN Q13043 Serine/threonine-protein Kinase MST1, Human 220 0.27 Binding ≤ 1μM
STK3_MOUSE Q9JI10 Serine/threonine-protein Kinase MST2, Mouse 90 0.28 Binding ≤ 1μM
STK3_HUMAN Q13188 Serine/threonine-protein Kinase MST2, Human 960 0.24 Binding ≤ 1μM
PIM1_HUMAN P11309 Serine/threonine-protein Kinase PIM1, Human 200 0.27 Binding ≤ 1μM
PIM2_HUMAN Q9P1W9 Serine/threonine-protein Kinase PIM2, Human 130 0.28 Binding ≤ 1μM
PIM3_HUMAN Q86V86 Serine/threonine-protein Kinase PIM3, Human 12 0.32 Binding ≤ 1μM
PLK4_HUMAN O00444 Serine/threonine-protein Kinase PLK4, Human 370 0.26 Binding ≤ 1μM
RIOK1_HUMAN Q9BRS2 Serine/threonine-protein Kinase RIO1, Human 810 0.24 Binding ≤ 1μM
KIT_HUMAN P10721 Stem Cell Growth Factor Receptor, Human 380 0.26 Binding ≤ 1μM
JAK3_HUMAN P52333 Tyrosine-protein Kinase JAK3, Human 420 0.26 Binding ≤ 1μM
FLT3_HUMAN P36888 Tyrosine-protein Kinase Receptor FLT3, Human 130 0.28 Binding ≤ 1μM
PDPK1_HUMAN O15530 3-phosphoinositide Dependent Protein Kinase-1, Human 700 0.25 Binding ≤ 10μM
AAK1_HUMAN Q2M2I8 Adaptor-associated Kinase, Human 900 0.24 Binding ≤ 10μM
BMP2K_HUMAN Q9NSY1 BMP-2-inducible Protein Kinase, Human 2500 0.22 Binding ≤ 10μM
KCC1A_HUMAN Q14012 CaM Kinase I Alpha, Human 6200 0.21 Binding ≤ 10μM
KCC1D_HUMAN Q8IU85 CaM Kinase I Delta, Human 2600 0.22 Binding ≤ 10μM
KCC2A_HUMAN Q9UQM7 CaM Kinase II Alpha, Human 6200 0.21 Binding ≤ 10μM
KCC2B_HUMAN Q13554 CaM Kinase II Beta, Human 6200 0.21 Binding ≤ 10μM
KCC2D_HUMAN Q13557 CaM Kinase II Delta, Human 6200 0.21 Binding ≤ 10μM
KCC2G_HUMAN Q13555 CaM Kinase II Gamma, Human 6200 0.21 Binding ≤ 10μM
KCC4_HUMAN Q16566 CaM Kinase IV, Human 6200 0.21 Binding ≤ 10μM
KKCC1_HUMAN Q8N5S9 CaM-kinase Kinase Alpha, Human 1500 0.23 Binding ≤ 10μM
KKCC2_HUMAN Q96RR4 CaM-kinase Kinase Beta, Human 1100 0.24 Binding ≤ 10μM
KAPCA_HUMAN P17612 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Human 5400 0.21 Binding ≤ 10μM
KAPCB_HUMAN P22694 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Human 3200 0.22 Binding ≤ 10μM
CSK21_HUMAN P68400 Casein Kinase II Alpha, Human 3600 0.22 Binding ≤ 10μM
CSK22_HUMAN P19784 Casein Kinase II Alpha (prime), Human 3400 0.22 Binding ≤ 10μM
KGP2_HUMAN Q13237 CGMP-dependent Protein Kinase 2, Human 3100 0.22 Binding ≤ 10μM
CTRO_HUMAN O14578 Citron Rho-interacting Kinase, Human 1400 0.23 Binding ≤ 10μM
DAPK1_HUMAN P53355 Death-associated Protein Kinase 1, Human 970 0.24 Binding ≤ 10μM
DAPK2_HUMAN Q9UIK4 Death-associated Protein Kinase 2, Human 2600 0.22 Binding ≤ 10μM
DAPK3_HUMAN O43293 Death-associated Protein Kinase 3, Human 1300 0.24 Binding ≤ 10μM
MP2K4_HUMAN P45985 Dual Specificity Mitogen-activated Protein Kinase Kinase 4, Human 930 0.24 Binding ≤ 10μM
CLK2_HUMAN P49760 Dual Specificity Protein Kinase CLK2, Human 420 0.26 Binding ≤ 10μM
CLK4_HUMAN Q9HAZ1 Dual Specificity Protein Kinase CLK4, Human 1900 0.23 Binding ≤ 10μM
DYR1B_HUMAN Q9Y463 Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Human 5400 0.21 Binding ≤ 10μM
CLK1_HUMAN P49759 Dual Specificty Protein Kinase CLK1, Human 910 0.24 Binding ≤ 10μM
FGFR1_HUMAN P11362 Fibroblast Growth Factor Receptor 1, Human 5100 0.21 Binding ≤ 10μM
GSK3B_HUMAN P49841 Glycogen Synthase Kinase-3 Beta, Human 2600 0.22 Binding ≤ 10μM
MARK2_HUMAN Q7KZI7 MAP/microtubule Affinity-regulating Kinase 2, Human 2300 0.23 Binding ≤ 10μM
MK15_HUMAN Q8TD08 Mitogen-activated Protein Kinase 15, Human 88 0.28 Binding ≤ 10μM
M3K9_HUMAN P80192 Mitogen-activated Protein Kinase Kinase Kinase 9, Human 1400 0.23 Binding ≤ 10μM
M4K1_HUMAN Q92918 Mitogen-activated Protein Kinase Kinase Kinase Kinase 1, Human 2600 0.22 Binding ≤ 10μM
M4K3_HUMAN Q8IVH8 Mitogen-activated Protein Kinase Kinase Kinase Kinase 3, Human 8400 0.20 Binding ≤ 10μM
M4K5_HUMAN Q9Y4K4 Mitogen-activated Protein Kinase Kinase Kinase Kinase 5, Human 8400 0.20 Binding ≤ 10μM
MYLK_HUMAN Q15746 Myosin Light Chain Kinase, Smooth Muscle, Human 290 0.26 Binding ≤ 10μM
DMPK_HUMAN Q09013 Myotonin-protein Kinase, Human 280 0.26 Binding ≤ 10μM
NUAK1_HUMAN O60285 NUAK Family SNF1-like Kinase 1, Human 1800 0.23 Binding ≤ 10μM
NUAK2_HUMAN Q9H093 NUAK Family SNF1-like Kinase 2, Human 320 0.26 Binding ≤ 10μM
PI51A_HUMAN Q99755 Phosphatidylinositol-4-phosphate 5-kinase Type-1 Alpha, Human 690 0.25 Binding ≤ 10μM
PI42B_HUMAN P78356 Phosphatidylinositol-5-phosphate 4-kinase Type-2 Beta, Human 830 0.24 Binding ≤ 10μM
PHKG1_HUMAN Q16816 Phosphorylase Kinase Gamma Subunit 1, Human 2700 0.22 Binding ≤ 10μM
PGFRB_HUMAN P09619 Platelet-derived Growth Factor Receptor Beta, Human 7000 0.21 Binding ≤ 10μM
KPCA_HUMAN P17252 Protein Kinase C Alpha, Human 360 0.26 Binding ≤ 10μM
KPCA_RAT P05696 Protein Kinase C Alpha, Rat 320 0.26 Binding ≤ 10μM
KPCB_RAT P68403 Protein Kinase C Beta, Rat 320 0.26 Binding ≤ 10μM
KPCB_HUMAN P05771 Protein Kinase C Beta, Human 4.7 0.33 Binding ≤ 10μM
KPCD_RAT P09215 Protein Kinase C Delta, Rat 320 0.26 Binding ≤ 10μM
KPCD_HUMAN Q05655 Protein Kinase C Delta, Human 250 0.26 Binding ≤ 10μM
KPCE_RAT P09216 Protein Kinase C Epsilon, Rat 320 0.26 Binding ≤ 10μM
KPCE_HUMAN Q02156 Protein Kinase C Epsilon, Human 600 0.25 Binding ≤ 10μM
KPCL_HUMAN P24723 Protein Kinase C Eta, Human 52 0.29 Binding ≤ 10μM
KPCL_RAT Q64617 Protein Kinase C Eta, Rat 320 0.26 Binding ≤ 10μM
KPCG_RAT P63319 Protein Kinase C Gamma, Rat 320 0.26 Binding ≤ 10μM
KPCG_HUMAN P05129 Protein Kinase C Gamma, Human 300 0.26 Binding ≤ 10μM
KPCT_RAT Q9WTQ0 Protein Kinase C Theta, Rat 320 0.26 Binding ≤ 10μM
KPCT_HUMAN Q04759 Protein Kinase C Theta, Human 2.5 0.34 Binding ≤ 10μM
KPCZ_RAT P09217 Protein Kinase C Zeta, Rat 320 0.26 Binding ≤ 10μM
PKN1_HUMAN Q16512 Protein Kinase N1, Human 350 0.26 Binding ≤ 10μM
PKN2_HUMAN Q16513 Protein Kinase N2, Human 1500 0.23 Binding ≤ 10μM
KS6A1_HUMAN Q15418 Ribosomal Protein S6 Kinase Alpha 1, Human 400 0.26 Binding ≤ 10μM
KS6A2_HUMAN Q15349 Ribosomal Protein S6 Kinase Alpha 2, Human 1500 0.23 Binding ≤ 10μM
KS6A3_HUMAN P51812 Ribosomal Protein S6 Kinase Alpha 3, Human 2200 0.23 Binding ≤ 10μM
KS6A4_HUMAN O75676 Ribosomal Protein S6 Kinase Alpha 4, Human 6100 0.21 Binding ≤ 10μM
KS6A5_HUMAN O75582 Ribosomal Protein S6 Kinase Alpha 5, Human 1300 0.24 Binding ≤ 10μM
KS6A6_HUMAN Q9UK32 Ribosomal Protein S6 Kinase Alpha 6, Human 2300 0.23 Binding ≤ 10μM
STK10_HUMAN O94804 Serine/threonine-protein Kinase 10, Human 1100 0.24 Binding ≤ 10μM
SLK_HUMAN Q9H2G2 Serine/threonine-protein Kinase 2, Human 400 0.26 Binding ≤ 10μM
STK33_HUMAN Q9BYT3 Serine/threonine-protein Kinase 33, Human 3100 0.22 Binding ≤ 10μM
AKT3_HUMAN Q9Y243 Serine/threonine-protein Kinase AKT3, Human 1400 0.23 Binding ≤ 10μM
AURKC_HUMAN Q9UQB9 Serine/threonine-protein Kinase Aurora-C, Human 3000 0.22 Binding ≤ 10μM
CHK1_HUMAN O14757 Serine/threonine-protein Kinase Chk1, Human 540 0.25 Binding ≤ 10μM
KPCD2_HUMAN Q9BZL6 Serine/threonine-protein Kinase D2, Human 890 0.24 Binding ≤ 10μM
GAK_HUMAN O14976 Serine/threonine-protein Kinase GAK, Human 1100 0.24 Binding ≤ 10μM
LATS1_HUMAN O95835 Serine/threonine-protein Kinase LATS1, Human 2600 0.22 Binding ≤ 10μM
LATS2_HUMAN Q9NRM7 Serine/threonine-protein Kinase LATS2, Human 640 0.25 Binding ≤ 10μM
STK4_HUMAN Q13043 Serine/threonine-protein Kinase MST1, Human 220 0.27 Binding ≤ 10μM
STK3_HUMAN Q13188 Serine/threonine-protein Kinase MST2, Human 960 0.24 Binding ≤ 10μM
STK3_MOUSE Q9JI10 Serine/threonine-protein Kinase MST2, Mouse 90 0.28 Binding ≤ 10μM
CDK16_HUMAN Q00536 Serine/threonine-protein Kinase PCTAIRE-1, Human 8000 0.20 Binding ≤ 10μM
PIM1_HUMAN P11309 Serine/threonine-protein Kinase PIM1, Human 200 0.27 Binding ≤ 10μM
PIM2_HUMAN Q9P1W9 Serine/threonine-protein Kinase PIM2, Human 130 0.28 Binding ≤ 10μM
PIM3_HUMAN Q86V86 Serine/threonine-protein Kinase PIM3, Human 12 0.32 Binding ≤ 10μM
PLK4_HUMAN O00444 Serine/threonine-protein Kinase PLK4, Human 370 0.26 Binding ≤ 10μM
RIOK1_HUMAN Q9BRS2 Serine/threonine-protein Kinase RIO1, Human 810 0.24 Binding ≤ 10μM
KIT_HUMAN P10721 Stem Cell Growth Factor Receptor, Human 380 0.26 Binding ≤ 10μM
TNIK_HUMAN Q9UKE5 TRAF2- And NCK-interacting Kinase, Human 5800 0.21 Binding ≤ 10μM
HCK_HUMAN P08631 Tyrosine-protein Kinase HCK, Human 2800 0.22 Binding ≤ 10μM
JAK3_HUMAN P52333 Tyrosine-protein Kinase JAK3, Human 420 0.26 Binding ≤ 10μM
LCK_HUMAN P06239 Tyrosine-protein Kinase LCK, Human 1300 0.24 Binding ≤ 10μM
FLT3_HUMAN P36888 Tyrosine-protein Kinase Receptor FLT3, Human 130 0.28 Binding ≤ 10μM
Z100405 Z100405 MV4-11 (Myeloid Leukemia Cells) 1500 0.23 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Acetylcholine regulates insulin secretion
Activation of ATR in response to replication stress
Activation of BAD and translocation to mitochondria
Activation of CaMK IV
Activation of NF-kappaB in B cells
Activation of PKB
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
APC truncation mutants have impaired AXIN binding
Apoptotic cleavage of cellular proteins
AXIN missense mutants destabilize the destruction complex
Beta-catenin phosphorylation cascade
Ca2+ pathway
Calmodulin induced events
CaMK IV-mediated phosphorylation of CREB
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
cGMP effects
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Condensation of Prometaphase Chromosomes
Constitutive PI3K/AKT Signaling in Cancer
CREB phosphorylation
CREB phosphorylation through the activation of Adenylate Cyclase
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of CaMKK
CREB phosphorylation through the activation of Ras
CRMPs in Sema3A signaling
CTLA4 inhibitory signaling
DAG and IP3 signaling
DAP12 signaling
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Depolymerisation of the Nuclear Lamina
disassembly of the destruction complex and recruitment of AXIN to the membrane
Disinhibition of SNARE formation
Downregulation of ERBB2:ERBB3 signaling
Downstream signal transduction
Downstream TCR signaling
Effects of PIP2 hydrolysis
EGFR Transactivation by Gastrin
ERK/MAPK targets
Factors involved in megakaryocyte development and platelet production
FCERI mediated MAPK activation
FCERI mediated NF-kB activation
FCGR activation
G alpha (z) signalling events
G beta:gamma signalling through PI3Kgamma
G2/M DNA damage checkpoint
Gastrin-CREB signalling pathway via PKC and MAPK
Generation of second messenger molecules
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Gluconeogenesis
Glycogen breakdown (glycogenolysis)
Golgi Associated Vesicle Biogenesis
GPVI-mediated activation cascade
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
HSF1-dependent transactivation
HuR stabilizes mRNA
Inactivation, recovery and regulation of the phototransduction cascade
Integrin alphaIIb beta3 signaling
Interferon gamma signaling
Interleukin receptor SHC signaling
Interleukin-1 signaling
Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signaling
Interleukin-7 signaling
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human
Loss of Nlp from mitotic centrosomes
Loss of proteins required for interphase microtubule organization from the ce
misspliced GSK3beta mutants stabilize beta-catenin
NCAM signaling for neurite out-growth
Nef and signal transduction
Nef Mediated CD4 Down-regulation
Negative regulation of the PI3K/AKT network
Netrin-1 signaling
Oxidative Stress Induced Senescence
PD-1 signaling
PECAM1 interactions
Phosphorylation of CD3 and TCR zeta chains
PIP3 activates AKT signaling
PKA activation
PKA activation in glucagon signalling
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Rap1 signalling
Ras activation uopn Ca2+ infux through NMDA receptor
Recruitment of mitotic centrosome proteins and complexes
Recycling pathway of L1
Regulation of HSF1-mediated heat shock response
Regulation of insulin secretion
Regulation of KIT signaling
Regulation of PLK1 Activity at G2/M Transition
Regulation of signaling by CBL
Response to elevated platelet cytosolic Ca2+
Role of DCC in regulating apoptosis
Role of LAT2/NTAL/LAB on calcium mobilization
Role of phospholipids in phagocytosis
RSK activation
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
Senescence-Associated Secretory Phenotype (SASP)
Signal transduction by L1
Signaling by activated point mutants of FGFR1
Signaling by FGFR mutants
Signaling by Hippo
Signaling by PDGF
Signaling by SCF-KIT
Smooth Muscle Contraction
Syndecan interactions
Synthesis of PIPs at the plasma membrane
T41 mutants of beta-catenin aren't phosphorylated
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Transcriptional activation of mitochondrial biogenesis
Translocation of ZAP-70 to Immunological synapse
truncations of AMER1 destabilize the destruction complex
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Unblocking of NMDA receptor, glutamate binding and activation
Uptake and function of anthrax toxins
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
VEGFR2 mediated vascular permeability
WNT mediated activation of DVL
WNT5A-dependent internalization of FZD4

Analogs ( Draw Identity 99% 90% 80% 70% )