In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
January 13th, 2010 | 27 | Yes |
Popular Name: 3-[4-[[3-(2,6-dimethylphenyl)phenyl]methoxy]phenyl]propanoic 3-[4-[[3-(2,6-dimethylphenyl)phe…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 6.10 | 14.56 | -46.66 | 0 | 3 | -1 | 49 | 359.445 | 7 | ↓ |
Lo Low (pH 4.5-6) | 6.10 | 12.59 | -9.18 | 1 | 3 | 0 | 47 | 360.453 | 7 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
FFAR1-1-E | Free Fatty Acid Receptor 1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 9 | 0.42 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
FFAR1_HUMAN | O14842 | Free Fatty Acid Receptor 1, Human | 8.8 | 0.42 | Functional ≤ 10μM |
Description | Species |
---|---|
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | |
Free fatty acid receptors | |
G alpha (q) signalling events | |
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | |
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polyp |