| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 29th, 2005 | 13 | Yes |
Popular Name: LY354740 LY354740
Find On: PubMed — Wikipedia — Google
CAS Numbers: 176199-48-7 , 177317-28-1 , 209216-09-1 , 209683-36-3
(1R,4S,5S,6S)-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylic acid
(1R,4S,5S,6S)-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylic acid hydrate
(1S,2S,5R,6S)-2-Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid monohydrate
(1S,2S,5R,6S)-2-Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid
(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
176199-48-7; D08908; Eglumegad (INN)
2-Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic acid
2-AMINOBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID HYDRATE
2-AMINOBICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLICACIDHYDRATE
209216-09-1; D03966; Eglumegad hydrate; Eglumetad (USAN)
4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Bicyclo(3.1.0)hexane-2,6-dicarboxylic acid, 2-amino-
Bicyclo(3.1.0)hexane-2,6-dicarboxylic acid, 2-amino-, monohydrate,(1S,2S,5R,6S)-
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino- (9CI)
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -1.97 | -2.62 | -80.5 | 3 | 5 | -1 | 107 | 184.171 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 85 | 0.76 | Binding ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 93 | 0.76 | Binding ≤ 10μM |
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5 | 0.89 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 38 | 0.80 | Functional ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3000 | 0.59 | Functional ≤ 10μM |
| Z50597-7-O | Rattus Norvegicus (cluster #7 Of 12), Other | Other | 86 | 0.76 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 13 | 0.85 | Binding ≤ 1μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 180 | 0.73 | Binding ≤ 1μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 125.6 | 0.74 | Binding ≤ 1μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 180 | 0.73 | Binding ≤ 1μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 13 | 0.85 | Binding ≤ 10μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 180 | 0.73 | Binding ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 180 | 0.73 | Binding ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 125.6 | 0.74 | Binding ≤ 10μM |
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 10 | 0.86 | Functional ≤ 10μM |
| GRM2_RAT | P31421 | Metabotropic Glutamate Receptor 2, Rat | 18.3 | 0.83 | Functional ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 24.3 | 0.82 | Functional ≤ 10μM |
| GRM3_RAT | P31422 | Metabotropic Glutamate Receptor 3, Rat | 32 | 0.81 | Functional ≤ 10μM |
| GRM6_HUMAN | O15303 | Metabotropic Glutamate Receptor 6, Human | 2990 | 0.59 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 55 | 0.78 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events |
