| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 30th, 2005 | 26 | Yes |
Popular Name: p38MAPKinaseInhibitor p38MAPKinaseInhibitor
Find On: PubMed — Wikipedia — Google
CAS Number: 219138-24-6
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.06 | 10.42 | -12.17 | 1 | 4 | 0 | 51 | 365.795 | 3 | ↓ |
| Lo Low (pH 4.5-6) | 4.51 | 8.97 | -41.42 | 2 | 4 | 1 | 52 | 366.803 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MK14-1-E | MAP Kinase P38 Alpha (cluster #1 Of 3), Eukaryotic | Eukaryotes | 35 | 0.40 | Binding ≤ 10μM |
| Z80548-1-O | THP-1 (Acute Monocytic Leukemia Cells) (cluster #1 Of 5), Other | Other | 4224 | 0.29 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MK14_HUMAN | Q16539 | MAP Kinase P38 Alpha, Human | 35 | 0.40 | Binding ≤ 1μM |
| MK14_RAT | P70618 | MAP Kinase P38 Alpha, Rat | 35 | 0.40 | Binding ≤ 1μM |
| MK14_MOUSE | P47811 | MAP Kinase P38 Alpha, Mouse | 35 | 0.40 | Binding ≤ 1μM |
| MK14_HUMAN | Q16539 | MAP Kinase P38 Alpha, Human | 35 | 0.40 | Binding ≤ 10μM |
| MK14_RAT | P70618 | MAP Kinase P38 Alpha, Rat | 35 | 0.40 | Binding ≤ 10μM |
| MK14_MOUSE | P47811 | MAP Kinase P38 Alpha, Mouse | 35 | 0.40 | Binding ≤ 10μM |
| Z80548 | Z80548 | THP-1 (Acute Monocytic Leukemia Cells) | 4224 | 0.29 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| activated TAK1 mediates p38 MAPK activation | |
| Activation of PPARGC1A (PGC-1alpha) by phosphorylation | |
| Activation of the AP-1 family of transcription factors | |
| ADP signalling through P2Y purinoceptor 1 | |
| CDO in myogenesis | |
| DSCAM interactions | |
| ERK/MAPK targets | |
| KSRP destabilizes mRNA | |
| NOD1/2 Signaling Pathway | |
| Oxidative Stress Induced Senescence | |
| p38MAPK events | |
| Platelet sensitization by LDL | |
| VEGFA-VEGFR2 Pathway |
