| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 4th, 2005 | 13 | Yes |
Popular Name: ENDOTHAL ENDOTHAL
Find On: PubMed — Wikipedia — Google
CAS Numbers: 129-67-9 , 145-73-3 , 28874-45-5 , 62059-43-2
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -0.23 | 4.09 | -137.03 | 0 | 5 | -2 | 89 | 184.147 | 2 | ↓ |
| Lo Low (pH 4.5-6) | -0.23 | 2.15 | -53.64 | 1 | 5 | -1 | 87 | 185.155 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| PUBCHEM_PATENT_ID | US5047574; US5175341; US5183909; US5241104 | IBM Patent Data |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PP2AA-1-E | Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform (cluster #1 Of 1), Eukaryotic | Eukaryotes | 170 | 0.73 | Binding ≤ 10μM |
| PP2AB-1-E | Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform (cluster #1 Of 1), Eukaryotic | Eukaryotes | 170 | 0.73 | Binding ≤ 10μM |
| PPM1J-1-E | Protein Phosphatase 2A Catalytic Subunit Zeta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 170 | 0.73 | Binding ≤ 10μM |
| Z50425-1-O | Plasmodium Falciparum (cluster #1 Of 22), Other | Other | 7800 | 0.55 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PPM1J_MOUSE | Q149T7 | Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse | 170 | 0.73 | Binding ≤ 1μM |
| PP2AA_MOUSE | P63330 | Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse | 170 | 0.73 | Binding ≤ 1μM |
| PP2AB_HUMAN | P62714 | Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human | 170 | 0.73 | Binding ≤ 1μM |
| PPM1J_MOUSE | Q149T7 | Protein Phosphatase 2A Catalytic Subunit Zeta, Mouse | 170 | 0.73 | Binding ≤ 10μM |
| PP2AA_MOUSE | P63330 | Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform, Mouse | 170 | 0.73 | Binding ≤ 10μM |
| PP2AB_HUMAN | P62714 | Serine/threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform, Human | 170 | 0.73 | Binding ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 7800 | 0.55 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| APC truncation mutants have impaired AXIN binding | |
| AXIN missense mutants destabilize the destruction complex | |
| Beta-catenin phosphorylation cascade | |
| CTLA4 inhibitory signaling | |
| Cyclin A/B1 associated events during G2/M transition | |
| Cyclin D associated events in G1 | |
| DARPP-32 events | |
| Degradation of beta-catenin by the destruction complex | |
| disassembly of the destruction complex and recruitment of AXIN to the membrane | |
| ERK/MAPK targets | |
| ERKs are inactivated | |
| Glycolysis | |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | |
| Initiation of Nuclear Envelope Reformation | |
| Integration of energy metabolism | |
| MASTL Facilitates Mitotic Progression | |
| misspliced GSK3beta mutants stabilize beta-catenin | |
| Mitotic Prometaphase | |
| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | |
| Platelet sensitization by LDL | |
| PP2A-mediated dephosphorylation of key metabolic factors | |
| Resolution of Sister Chromatid Cohesion | |
| S33 mutants of beta-catenin aren't phosphorylated | |
| S37 mutants of beta-catenin aren't phosphorylated | |
| S45 mutants of beta-catenin aren't phosphorylated | |
| Separation of Sister Chromatids | |
| Spry regulation of FGF signaling | |
| T41 mutants of beta-catenin aren't phosphorylated | |
| truncations of AMER1 destabilize the destruction complex |
