| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 1st, 2010 | 27 | Yes |
Popular Name: N,N-diethyl-2-(N-(4-ethylphenyl)sulfonyl-4-methyl-anilino)acetamide N,N-diethyl-2-(N-(4-ethylphenyl)…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.41 | 10.44 | -19.44 | 0 | 5 | 0 | 58 | 388.533 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| OX2R-1-E | Orexin Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 89 | 0.37 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| OX2R_HUMAN | O43614 | Orexin Receptor 2, Human | 89 | 0.37 | Binding ≤ 1μM |
| OX2R_HUMAN | O43614 | Orexin Receptor 2, Human | 89 | 0.37 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (q) signalling events | |
| Orexin and neuropeptides FF and QRFP bind to their respective receptors |
