In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
October 18th, 2005 | 33 | No |
Popular Name: 1-[4-(bromo-chloro-BLAHyl)-1-piperidyl]-2-(1-oxido-4-pyridyl)-ethanone 1-[4-(bromo-chloro-BLAHyl)-1-pip…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.89 | 0.11 | -26.3 | 0 | 5 | 0 | 58 | 526.862 | 3 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
FNTA-1-E | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #1 Of 3), Eukaryotic | Eukaryotes | 40 | 0.31 | Binding ≤ 10μM |
FNTB-1-E | Protein Farnesyltransferase Beta Subunit (cluster #1 Of 3), Eukaryotic | Eukaryotes | 40 | 0.31 | Binding ≤ 10μM |
Z80106-1-O | COS-1 (Kidney Cells) (cluster #1 Of 1), Other | Other | 400 | 0.27 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 40 | 0.31 | Binding ≤ 1μM |
FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 40 | 0.31 | Binding ≤ 1μM |
FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 40 | 0.31 | Binding ≤ 10μM |
FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 40 | 0.31 | Binding ≤ 10μM |
Z80106 | Z80106 | COS-1 (Kidney Cells) | 400 | 0.27 | Functional ≤ 10μM |
Description | Species |
---|---|
Apoptotic cleavage of cellular proteins | |
Inactivation, recovery and regulation of the phototransduction cascade |