| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 20th, 2005 | 43 | No |
Popular Name: methyl methyl
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.12 | -4.86 | -20.96 | 2 | 8 | 0 | 94 | 615.777 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DLK1-1-E | Protein Delta Homolog 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 114 | 0.23 | Binding ≤ 10μM |
| KPCA-1-E | Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic | Eukaryotes | 16 | 0.25 | Binding ≤ 10μM |
| KPCB-1-E | Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 16 | 0.25 | Binding ≤ 10μM |
| KPCD-1-E | Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic | Eukaryotes | 16 | 0.25 | Binding ≤ 10μM |
| KPCE-1-E | Protein Kinase C Epsilon (cluster #1 Of 5), Eukaryotic | Eukaryotes | 16 | 0.25 | Binding ≤ 10μM |
| KPCG-1-E | Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic | Eukaryotes | 16 | 0.25 | Binding ≤ 10μM |
| KPCL-2-E | Protein Kinase C Eta (cluster #2 Of 4), Eukaryotic | Eukaryotes | 16 | 0.25 | Binding ≤ 10μM |
| KPCT-1-E | Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic | Eukaryotes | 16 | 0.25 | Binding ≤ 10μM |
| KPCZ-1-E | Protein Kinase C Zeta (cluster #1 Of 5), Eukaryotic | Eukaryotes | 16 | 0.25 | Binding ≤ 10μM |
| M3K10-1-E | Mitogen-activated Protein Kinase Kinase Kinase 10 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 51 | 0.24 | Binding ≤ 10μM |
| M3K11-1-E | Mitogen-activated Protein Kinase Kinase Kinase 11 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 64 | 0.23 | Binding ≤ 10μM |
| M3K9-1-E | Mitogen-activated Protein Kinase Kinase Kinase 9 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 72 | 0.23 | Binding ≤ 10μM |
| VGFR1-1-E | Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 209 | 0.22 | Binding ≤ 10μM |
| VGFR2-1-E | Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 43 | 0.24 | Binding ≤ 10μM |
| VGFR3-1-E | Vascular Endothelial Growth Factor Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 39 | 0.24 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| M3K10_HUMAN | Q02779 | Mitogen-activated Protein Kinase Kinase Kinase 10, Human | 51 | 0.24 | Binding ≤ 1μM |
| M3K11_HUMAN | Q16584 | Mitogen-activated Protein Kinase Kinase Kinase 11, Human | 23.1 | 0.25 | Binding ≤ 1μM |
| M3K9_HUMAN | P80192 | Mitogen-activated Protein Kinase Kinase Kinase 9, Human | 38 | 0.24 | Binding ≤ 1μM |
| DLK1_HUMAN | P80370 | Protein Delta Homolog 1, Human | 114 | 0.23 | Binding ≤ 1μM |
| KPCA_RAT | P05696 | Protein Kinase C Alpha, Rat | 16.3 | 0.25 | Binding ≤ 1μM |
| KPCB_RAT | P68403 | Protein Kinase C Beta, Rat | 16.3 | 0.25 | Binding ≤ 1μM |
| KPCD_RAT | P09215 | Protein Kinase C Delta, Rat | 16.3 | 0.25 | Binding ≤ 1μM |
| KPCE_RAT | P09216 | Protein Kinase C Epsilon, Rat | 16.3 | 0.25 | Binding ≤ 1μM |
| KPCL_RAT | Q64617 | Protein Kinase C Eta, Rat | 16.3 | 0.25 | Binding ≤ 1μM |
| KPCG_RAT | P63319 | Protein Kinase C Gamma, Rat | 16.3 | 0.25 | Binding ≤ 1μM |
| KPCT_RAT | Q9WTQ0 | Protein Kinase C Theta, Rat | 16.3 | 0.25 | Binding ≤ 1μM |
| KPCZ_RAT | P09217 | Protein Kinase C Zeta, Rat | 16.3 | 0.25 | Binding ≤ 1μM |
| VGFR1_HUMAN | P17948 | Vascular Endothelial Growth Factor Receptor 1, Human | 209 | 0.22 | Binding ≤ 1μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 43 | 0.24 | Binding ≤ 1μM |
| VGFR3_HUMAN | P35916 | Vascular Endothelial Growth Factor Receptor 3, Human | 39 | 0.24 | Binding ≤ 1μM |
| M3K10_HUMAN | Q02779 | Mitogen-activated Protein Kinase Kinase Kinase 10, Human | 51 | 0.24 | Binding ≤ 10μM |
| M3K11_HUMAN | Q16584 | Mitogen-activated Protein Kinase Kinase Kinase 11, Human | 23.1 | 0.25 | Binding ≤ 10μM |
| M3K9_HUMAN | P80192 | Mitogen-activated Protein Kinase Kinase Kinase 9, Human | 38 | 0.24 | Binding ≤ 10μM |
| DLK1_HUMAN | P80370 | Protein Delta Homolog 1, Human | 114 | 0.23 | Binding ≤ 10μM |
| KPCA_RAT | P05696 | Protein Kinase C Alpha, Rat | 16.3 | 0.25 | Binding ≤ 10μM |
| KPCB_RAT | P68403 | Protein Kinase C Beta, Rat | 16.3 | 0.25 | Binding ≤ 10μM |
| KPCD_RAT | P09215 | Protein Kinase C Delta, Rat | 16.3 | 0.25 | Binding ≤ 10μM |
| KPCE_RAT | P09216 | Protein Kinase C Epsilon, Rat | 16.3 | 0.25 | Binding ≤ 10μM |
| KPCL_RAT | Q64617 | Protein Kinase C Eta, Rat | 16.3 | 0.25 | Binding ≤ 10μM |
| KPCG_RAT | P63319 | Protein Kinase C Gamma, Rat | 16.3 | 0.25 | Binding ≤ 10μM |
| KPCT_RAT | Q9WTQ0 | Protein Kinase C Theta, Rat | 16.3 | 0.25 | Binding ≤ 10μM |
| KPCZ_RAT | P09217 | Protein Kinase C Zeta, Rat | 16.3 | 0.25 | Binding ≤ 10μM |
| VGFR1_HUMAN | P17948 | Vascular Endothelial Growth Factor Receptor 1, Human | 209 | 0.22 | Binding ≤ 10μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 43 | 0.24 | Binding ≤ 10μM |
| VGFR3_HUMAN | P35916 | Vascular Endothelial Growth Factor Receptor 3, Human | 39 | 0.24 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | |
| Activation of NF-kappaB in B cells | |
| Calmodulin induced events | |
| Depolymerisation of the Nuclear Lamina | |
| Disinhibition of SNARE formation | |
| Effects of PIP2 hydrolysis | |
| EPHA-mediated growth cone collapse | |
| G alpha (z) signalling events | |
| GPVI-mediated activation cascade | |
| Integrin cell surface interactions | |
| Neurophilin interactions with VEGF and VEGFR | |
| Response to elevated platelet cytosolic Ca2+ | |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | |
| Trafficking of GluR2-containing AMPA receptors | |
| VEGF binds to VEGFR leading to receptor dimerization | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation | |
| WNT5A-dependent internalization of FZD4 |
