| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 28th, 2005 | 23 | Yes |
Popular Name: Peramivir Peramivir
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1041434-82-5 , 330600-85-6 , [1041434-82-5]
(1S,2S,3R,4R)-3-((S)-1-Acetamido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentanecarboxylic acid
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -0.10 | 2.44 | -59.87 | 7 | 8 | 0 | 153 | 328.413 | 8 | ↓ |
| Hi High (pH 8-9.5) | 4.77 | 23.55 | -33.73 | 0 | 5 | 1 | 56 | 588.683 | 9 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Purity | 95% | Fluorochem |
| Target | Others | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NRAM-1-V | Neuraminidase (cluster #1 Of 2), Viral | Viruses | 5 | 0.51 | Binding ≤ 10μM |
| Z50522-1-O | Unidentified Influenza Virus (cluster #1 Of 2), Other | Other | 8400 | 0.31 | Functional ≤ 10μM |
| Z50523-1-O | Influenza B Virus (cluster #1 Of 1), Other | Other | 3 | 0.52 | Functional ≤ 10μM |
| Z50652-1-O | Influenza A Virus (cluster #1 Of 4), Other | Other | 98 | 0.43 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NRAM_I34A1 | P03468 | Neuraminidase, I34a1 | 1 | 0.55 | Binding ≤ 1μM |
| NRAM_INBLE | P03474 | Neuraminidase, Inble | 11 | 0.48 | Binding ≤ 1μM |
| NRAM_INBLE | P03474 | Neuraminidase, Inble | 11 | 0.48 | Binding ≤ 10μM |
| NRAM_I34A1 | P03468 | Neuraminidase, I34a1 | 1 | 0.55 | Binding ≤ 10μM |
| Z50652 | Z50652 | Influenza A Virus | 0.1 | 0.61 | Functional ≤ 10μM |
| Z50523 | Z50523 | Influenza B Virus | 3 | 0.52 | Functional ≤ 10μM |
| Z50522 | Z50522 | Unidentified Influenza Virus | 8400 | 0.31 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Assembly of Viral Components at the Budding Site | |
| Budding | |
| Entry of Influenza Virion into Host Cell via Endocytosis | |
| Fusion of the Influenza Virion to the Host Cell Endosome | |
| Influenza Life Cycle | |
| Influenza Virus Induced Apoptosis | |
| Packaging of Eight RNA Segments | |
| Release | |
| Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticul | |
| Uncoating of the Influenza Virion | |
| Viral mRNA Translation |
