UCSF

ZINC04025285

Substance Information

In ZINC since Heavy atoms Benign functionality
November 2nd, 2005 28 No

CAS Number: 595-33-5

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.09 11.54 -14.95 0 4 0 60 384.516 3

Vendor Notes

Note Type Comments Provided By
mechanism . ZereneX Building Blocks
MP 218 TCI
biological_use against carcinoma of the breast and endometrium IBScreen Bioactives
mechanism Also has direct cytotoxic effects on breast cancer cells in tissue culture and suppresses luteinising hormone release from the pituitary IBScreen Bioactives
biological_use Antineoplastic agent IBScreen Bioactives
biological_use Oral contraceptive IBScreen Bioactives ZereneX Building Blocks
mechanism The biochemical mechanism of progestin antitumour activity is not well but may involve interaction with progesterone and glucocorticoid receptors, androgenic properties IBScreen Bioactives
mechanism The precise mechanism by which megestrol acetate produces effects in anorexia and cachexia is unknown at the present time IBScreen Bioactives IBScreen Bioactives

Activity (Go SEA)

Analogs ( Draw Identity 99% 90% 80% 70% )