UCSF

ZINC40405245

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Substance Information

In ZINC since Heavy atoms Benign functionality
April 6th, 2010 27 Yes

Popular Name: sFRP-1Inhibitor sFRP-1Inhibitor

Find On: PubMed — Wikipedia — Google

CAS Number: 915754-88-0

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.99 6.11 -49.8 2 6 1 85 411.569 9 ↓

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
SFRP1-1-E Secreted Frizzled-related Protein 1 (cluster #1 Of 1), Eukaryotic Eukaryotes 1270 0.31 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
SFRP1_HUMAN Q8N474 Secreted Frizzled-related Protein 1, Human 1270 0.31 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
negative regulation of TCF-dependent signaling by WNT ligand antagonists

Analogs ( Draw Identity 99% 90% 80% 70% )

No pre-computed analogs available. Try a structural similarity search.