| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 20th, 2010 | 17 | Yes |
Popular Name: N-cyclopropyl-2-[[(1S,2R)-2-phenylcyclopropyl]amino]acetamide N-cyclopropyl-2-[[(1S,2R)-2-phen…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.77 | 5.96 | -42.59 | 3 | 3 | 1 | 46 | 231.319 | 5 | ↓ |
| Hi High (pH 8-9.5) | 1.77 | 4.67 | -7.94 | 2 | 3 | 0 | 41 | 230.311 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KDM1A-1-E | Lysine-specific Histone Demethylase 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6000 | 0.43 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KDM1A_HUMAN | O60341 | Lysine-specific Histone Demethylase 1, Human | 6000 | 0.43 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Factors involved in megakaryocyte development and platelet production | |
| HDACs deacetylate histones | |
| HDMs demethylate histones |
