| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 23rd, 2010 | 32 | Yes |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.19 | 6.01 | -128.69 | 6 | 7 | 2 | 100 | 449.477 | 10 | ↓ |
| Mid Mid (pH 6-8) | 2.19 | 5.64 | -45.58 | 5 | 7 | 1 | 99 | 448.469 | 10 | ↓ |
| Mid Mid (pH 6-8) | 2.19 | 4.67 | -49.66 | 5 | 7 | 1 | 96 | 448.469 | 10 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CARM1-1-E | Histone-arginine Methyltransferase CARM1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1000 | 0.26 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CARM1_MOUSE | Q9WVG6 | Histone-arginine Methyltransferase CARM1, Mouse | 1000 | 0.26 | Binding ≤ 1μM |
| CARM1_MOUSE | Q9WVG6 | Histone-arginine Methyltransferase CARM1, Mouse | 1000 | 0.26 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of gene expression by SREBF (SREBP) | |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | |
| Circadian Clock | |
| PPARA activates gene expression | |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp | |
| REV-ERBA represses gene expression | |
| RMTs methylate histone arginines | |
| RORA activates circadian gene expression | |
| Transcriptional activation of mitochondrial biogenesis | |
| Transcriptional regulation of white adipocyte differentiation | |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression |
