| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 10th, 2010 | 34 | Yes |
Popular Name: AZD8055 AZD8055
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1009298-09-2 , [1009298-09-2]
(5-(2,4-Bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
[5-[2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.39 | 9.2 | -16.08 | 1 | 9 | 0 | 93 | 465.554 | 5 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Target | mTOR | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MTOR-2-E | Serine/threonine-protein Kinase MTOR (cluster #2 Of 3), Eukaryotic | Eukaryotes | 1 | 0.37 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MTOR_HUMAN | P42345 | FK506 Binding Protein 12, Human | 0.8 | 0.37 | Binding ≤ 1μM |
| MTOR_HUMAN | P42345 | FK506 Binding Protein 12, Human | 0.8 | 0.37 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| CD28 dependent PI3K/Akt signaling | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| HSF1-dependent transactivation | |
| mTOR signalling | |
| PIP3 activates AKT signaling | |
| Release of eIF4E | |
| S6K1-mediated signalling | |
| VEGFR2 mediated vascular permeability |
No pre-computed analogs available. Try a structural similarity search.
![Pyrido[2,3-d]pyrimidine](http://zinc12.docking.org/img/rings/421.gif)
![4-(2-morpholino-7-phenyl-pyrido[2,3-d]pyrimidin-4-yl)morpholine](http://zinc12.docking.org/img/rings/247710.gif)