| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| September 27th, 2005 | 24 | Yes |
Popular Name: Triflupromazine hydrochloride Triflupromazine hydrochloride
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1098-60-8 , 1098-60-8, 146-54-3 [trif , 1098-60-8, 146-54-3 [triflupromazine]
10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine
10-3-(Dimethylamino)propyl-2-(trifluoromethyl)phenothiazine
1098-60-8; D00800; Triflupromazine hydrochloride (JAN/USP); Vesprin (TN)
1098-60-8; Prestwick_893; Triflupromazine hydrochloride
10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-
2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine
Fluopromazine monohydrochloride
N,N-Dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine
N,N-dimethyl-3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)-1-propanamine
N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine
N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine
N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine hydrochloride
Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-
Trifluopromazine hydrochloride
triflupromazina; triflupromazine; triflupromazinum
Triflupromazine (hydrochloride)
USP); Triflupromazine HCl (FDA
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.25 | 12 | -43.24 | 1 | 2 | 1 | 9 | 353.433 | 5 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| ALOGPS_SOLUBILITY | 1.80e-03 g/l | DrugBank-approved |
| Therapy | antipsychotic | SMDC MicroSource |
| Patent Database Links | EP1627639; EP1829534; EP1884243; US2005080075; US2005176790; US2007207222; US2007259952; WO2007103687; WO2007124757; WO2007128442 | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CHLE-1-E | Butyrylcholinesterase (cluster #1 Of 7), Eukaryotic | Eukaryotes | 7400 | 0.30 | Binding ≤ 10μM |
| PDR5-1-F | Pleiotropic ABC Efflux Transporter Of Multiple Drugs (cluster #1 Of 1), Fungal | Fungi | 4900 | 0.31 | Binding ≤ 10μM |
| Z50425-3-O | Plasmodium Falciparum (cluster #3 Of 22), Other | Other | 6310 | 0.30 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| CHLE_HORSE | P81908 | Cholinesterase, Horse | 7400 | 0.30 | Binding ≤ 10μM |
| PDR5_YEAST | P33302 | Pleiotropic ABC Efflux Transporter Of Multiple Drugs, Yeast | 4900 | 0.31 | Binding ≤ 10μM |
| Z50425 | Z50425 | Plasmodium Falciparum | 10000 | 0.29 | Functional ≤ 10μM |
