| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| January 8th, 2011 | 44 | No |
Popular Name: 1-[(1S,2R,4R,5S)-2,4-bis(2,4-diguanidinophenoxy)-5-guanidino-cyclohexyl]guanidine 1-[(1S,2R,4R,5S)-2,4-bis(2,4-dig…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.66 | 3.72 | -348.6 | 29 | 20 | 5 | 399 | 615.732 | 16 | ↓ |
| Mid Mid (pH 6-8) | -2.66 | 3.25 | -466.17 | 30 | 20 | 6 | 400 | 616.74 | 16 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FURIN-2-E | Furin (cluster #2 Of 2), Eukaryotic | Eukaryotes | 169 | 0.22 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FURIN_HUMAN | P09958 | Furin, Human | 169 | 0.22 | Binding ≤ 1μM |
| FURIN_HUMAN | P09958 | Furin, Human | 169 | 0.22 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Collagen degradation | |
| Elastic fibre formation | |
| NGF processing | |
| Pre-NOTCH Processing in Golgi | |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |
| Signaling by NODAL | |
| Signaling by PDGF | |
| Synthesis and processing of ENV and VPU | |
| TGF-beta receptor signaling activates SMADs | |
| Uptake and function of anthrax toxins |
