UCSF

ZINC58638344

Draw Identity 99% 90% 80% 70%

Substance Information

In ZINC since Heavy atoms Benign functionality
February 11th, 2011 37 Yes

Popular Name: UNC0638 UNC0638

Find On: PubMed — Wikipedia — Google

CAS Number: 1255580-76-7

Other Names:

N/A

UNC 0638

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.93 15.8 -80.71 3 7 2 65 511.755 10 ↓
Lo Low (pH 4.5-6) 4.93 16.26 -139.39 4 7 3 66 512.763 10 ↓

Vendor Notes

Note Type Comments Provided By
Target Histone Methyltransferase Selleck Chemicals

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
EHMT2-1-E Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 3 (cluster #1 Of 1), Eukaryotic Eukaryotes 81 0.27 Binding ≤ 10μM
Z103196-1-O 22RV1 (cluster #1 Of 2), Other Other 4500 0.20 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
EHMT2_HUMAN Q96KQ7 Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 3, Human 12 0.30 Binding ≤ 1μM
EHMT2_HUMAN Q96KQ7 Histone-lysine N-methyltransferase, H3 Lysine-9 Specific 3, Human 12 0.30 Binding ≤ 10μM
Z103196 Z103196 22RV1 4500 0.20 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
RNA Polymerase I Transcription Initiation
Senescence-Associated Secretory Phenotype (SASP)

Analogs ( Draw Identity 99% 90% 80% 70% )