UCSF

ZINC00600534

Substance Information

In ZINC since Heavy atoms Benign functionality
September 27th, 2005 33 No

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.02 0.54 -50.32 2 6 1 64 439.539 3

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
KAPCA-1-E CAMP-dependent Protein Kinase Alpha-catalytic Subunit (cluster #1 Of 4), Eukaryotic Eukaryotes 7000 0.22 Binding ≤ 10μM
KAPCB-1-E CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit (cluster #1 Of 3), Eukaryotic Eukaryotes 7000 0.22 Binding ≤ 10μM
KCC2A-1-E CaM Kinase II Alpha (cluster #1 Of 1), Eukaryotic Eukaryotes 2000 0.24 Binding ≤ 10μM
KCC2B-1-E CaM Kinase II Beta (cluster #1 Of 1), Eukaryotic Eukaryotes 2000 0.24 Binding ≤ 10μM
KCC2D-1-E CaM Kinase II Delta (cluster #1 Of 1), Eukaryotic Eukaryotes 2000 0.24 Binding ≤ 10μM
KCC2G-1-E CaM Kinase II Gamma (cluster #1 Of 1), Eukaryotic Eukaryotes 2000 0.24 Binding ≤ 10μM
KPCA-1-E Protein Kinase C Alpha (cluster #1 Of 6), Eukaryotic Eukaryotes 400 0.27 Binding ≤ 10μM
KPCB-1-E Protein Kinase C Beta (cluster #1 Of 4), Eukaryotic Eukaryotes 200 0.28 Binding ≤ 10μM
KPCD-1-E Protein Kinase C Delta (cluster #1 Of 4), Eukaryotic Eukaryotes 400 0.27 Binding ≤ 10μM
KPCE-1-E Protein Kinase C Epsilon (cluster #1 Of 5), Eukaryotic Eukaryotes 400 0.27 Binding ≤ 10μM
KPCG-1-E Protein Kinase C Gamma (cluster #1 Of 4), Eukaryotic Eukaryotes 200 0.28 Binding ≤ 10μM
KPCL-2-E Protein Kinase C Eta (cluster #2 Of 4), Eukaryotic Eukaryotes 200 0.28 Binding ≤ 10μM
KPCT-1-E Protein Kinase C Theta (cluster #1 Of 3), Eukaryotic Eukaryotes 200 0.28 Binding ≤ 10μM
KPCZ-1-E Protein Kinase C Zeta (cluster #1 Of 5), Eukaryotic Eukaryotes 4000 0.23 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
KPCA_HUMAN P17252 Protein Kinase C Alpha, Human 400 0.27 Binding ≤ 1μM
KPCA_RAT P05696 Protein Kinase C Alpha, Rat 200 0.28 Binding ≤ 1μM
KPCB_HUMAN P05771 Protein Kinase C Beta, Human 10 0.34 Binding ≤ 1μM
KPCB_RAT P68403 Protein Kinase C Beta, Rat 200 0.28 Binding ≤ 1μM
KPCD_RAT P09215 Protein Kinase C Delta, Rat 200 0.28 Binding ≤ 1μM
KPCD_HUMAN Q05655 Protein Kinase C Delta, Human 400 0.27 Binding ≤ 1μM
KPCE_RAT P09216 Protein Kinase C Epsilon, Rat 200 0.28 Binding ≤ 1μM
KPCE_HUMAN Q02156 Protein Kinase C Epsilon, Human 400 0.27 Binding ≤ 1μM
KPCL_HUMAN P24723 Protein Kinase C Eta, Human 50 0.31 Binding ≤ 1μM
KPCL_RAT Q64617 Protein Kinase C Eta, Rat 200 0.28 Binding ≤ 1μM
KPCG_HUMAN P05129 Protein Kinase C Gamma, Human 500 0.27 Binding ≤ 1μM
KPCG_RAT P63319 Protein Kinase C Gamma, Rat 200 0.28 Binding ≤ 1μM
KPCT_RAT Q9WTQ0 Protein Kinase C Theta, Rat 200 0.28 Binding ≤ 1μM
KPCZ_RAT P09217 Protein Kinase C Zeta, Rat 200 0.28 Binding ≤ 1μM
KCC2A_HUMAN Q9UQM7 CaM Kinase II Alpha, Human 2000 0.24 Binding ≤ 10μM
KCC2B_HUMAN Q13554 CaM Kinase II Beta, Human 2000 0.24 Binding ≤ 10μM
KCC2D_HUMAN Q13557 CaM Kinase II Delta, Human 2000 0.24 Binding ≤ 10μM
KCC2G_HUMAN Q13555 CaM Kinase II Gamma, Human 2000 0.24 Binding ≤ 10μM
KAPCA_BOVIN P00517 CAMP-dependent Protein Kinase Alpha-catalytic Subunit, Bovin 7000 0.22 Binding ≤ 10μM
KAPCB_BOVIN P05131 CAMP-dependent Protein Kinase Beta-1 Catalytic Subunit, Bovin 7000 0.22 Binding ≤ 10μM
KPCA_RAT P05696 Protein Kinase C Alpha, Rat 200 0.28 Binding ≤ 10μM
KPCA_HUMAN P17252 Protein Kinase C Alpha, Human 400 0.27 Binding ≤ 10μM
KPCB_HUMAN P05771 Protein Kinase C Beta, Human 10 0.34 Binding ≤ 10μM
KPCB_RAT P68403 Protein Kinase C Beta, Rat 200 0.28 Binding ≤ 10μM
KPCD_RAT P09215 Protein Kinase C Delta, Rat 200 0.28 Binding ≤ 10μM
KPCD_HUMAN Q05655 Protein Kinase C Delta, Human 400 0.27 Binding ≤ 10μM
KPCE_RAT P09216 Protein Kinase C Epsilon, Rat 200 0.28 Binding ≤ 10μM
KPCE_HUMAN Q02156 Protein Kinase C Epsilon, Human 400 0.27 Binding ≤ 10μM
KPCL_HUMAN P24723 Protein Kinase C Eta, Human 50 0.31 Binding ≤ 10μM
KPCL_RAT Q64617 Protein Kinase C Eta, Rat 200 0.28 Binding ≤ 10μM
KPCG_HUMAN P05129 Protein Kinase C Gamma, Human 500 0.27 Binding ≤ 10μM
KPCG_RAT P63319 Protein Kinase C Gamma, Rat 200 0.28 Binding ≤ 10μM
KPCT_RAT Q9WTQ0 Protein Kinase C Theta, Rat 200 0.28 Binding ≤ 10μM
KPCZ_HUMAN Q05513 Protein Kinase C Zeta, Human 4000 0.23 Binding ≤ 10μM
KPCZ_RAT P09217 Protein Kinase C Zeta, Rat 200 0.28 Binding ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Acetylcholine regulates insulin secretion
Activation of NF-kappaB in B cells
Apoptotic cleavage of cellular proteins
Ca2+ pathway
Calmodulin induced events
CREB phosphorylation through the activation of Adenylate Cyclase
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
DAG and IP3 signaling
DARPP-32 events
Depolymerisation of the Nuclear Lamina
Disinhibition of SNARE formation
Effects of PIP2 hydrolysis
EGFR Transactivation by Gastrin
Factors involved in megakaryocyte development and platelet production
G alpha (z) signalling events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Gluconeogenesis
GPVI-mediated activation cascade
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
HSF1-dependent transactivation
HuR stabilizes mRNA
Inactivation, recovery and regulation of the phototransduction cascade
Interferon gamma signaling
Interleukin-3, 5 and GM-CSF signaling
Loss of Nlp from mitotic centrosomes
Loss of proteins required for interphase microtubule organization from the ce
PKA activation
PKA activation in glucagon signalling
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Rap1 signalling
Ras activation uopn Ca2+ infux through NMDA receptor
Recruitment of mitotic centrosome proteins and complexes
Regulation of insulin secretion
Regulation of KIT signaling
Regulation of PLK1 Activity at G2/M Transition
Response to elevated platelet cytosolic Ca2+
Role of phospholipids in phagocytosis
Signaling by SCF-KIT
Syndecan interactions
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFR2 mediated cell proliferation
WNT5A-dependent internalization of FZD4

Analogs ( Draw Identity 99% 90% 80% 70% )