| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 11th, 2006 | 9 | Yes |
Popular Name: 2-Amino-4-methoxypyridine 2-Amino-4-methoxypyridine
Find On: PubMed — Wikipedia — Google
CAS Numbers: 10201-73-1 , 10201-73-7 , 455-00-5 , [10201-73-7]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.53 | 0.78 | -5.41 | 2 | 3 | 0 | 48 | 124.143 | 1 | ↓ |
| Mid Mid (pH 6-8) | 0.53 | 1.08 | -29.41 | 3 | 3 | 1 | 49 | 125.151 | 1 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| MP | 120-121° | Matrix Scientific |
| purity | 9.500000000000000e+001 | Enamine Building Blocks Enamine Building Blocks |
| Purity | 98% | Matrix Scientific |
| MP | 99 - 101 | Enamine Building Blocks |
| MP | 99...101 | Enamine Building Blocks |
| Warnings | IRRITANT | Matrix Scientific |
| Warnings | Irritant-Harmful/Stored under Argon/Air Sensitive | Matrix Scientific |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NOS1-5-E | Nitric-oxide Synthase, Brain (cluster #5 Of 7), Eukaryotic | Eukaryotes | 1000 | 0.93 | Binding ≤ 10μM |
| NOS2-8-E | Nitric Oxide Synthase, Inducible (cluster #8 Of 9), Eukaryotic | Eukaryotes | 1000 | 0.93 | Binding ≤ 10μM |
| NOS3-6-E | Nitric Oxide Synthase, Endothelial (cluster #6 Of 7), Eukaryotic | Eukaryotes | 1000 | 0.93 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| NOS2_HUMAN | P35228 | Nitric Oxide Synthase, Inducible, Human | 1000 | 0.93 | Binding ≤ 1μM |
| NOS1_HUMAN | P29475 | Nitric-oxide Synthase, Brain, Human | 1000 | 0.93 | Binding ≤ 1μM |
| NOS3_HUMAN | P29474 | Nitric-oxide Synthase, Endothelial, Human | 1000 | 0.93 | Binding ≤ 1μM |
| NOS2_HUMAN | P35228 | Nitric Oxide Synthase, Inducible, Human | 1000 | 0.93 | Binding ≤ 10μM |
| NOS1_HUMAN | P29475 | Nitric-oxide Synthase, Brain, Human | 1000 | 0.93 | Binding ≤ 10μM |
| NOS3_HUMAN | P29474 | Nitric-oxide Synthase, Endothelial, Human | 1000 | 0.93 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| eNOS activation | |
| Nitric oxide stimulates guanylate cyclase | |
| NOSIP mediated eNOS trafficking | |
| NOSTRIN mediated eNOS trafficking | |
| Phagosomal maturation (early endosomal stage) | |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | |
| VEGFR2 mediated vascular permeability |
